{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T16:12:49Z","timestamp":1789488769948,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2024A04J4769"],"award-info":[{"award-number":["2024A04J4769"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2020A1515110670"],"award-info":[{"award-number":["2020A1515110670"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Psoriasis, a prevalent chronic inflammatory skin disease, substantially impairs patients' quality of life and is frequently linked to numerous systemic comorbidities. We aimed to investigate whether phenotypic age acceleration (PhenoAge\u2010accel) and obesity synergistically affect the risk of psoriasis. This analysis utilised data from 11\u2009344 participants in the 2003\u20132006 and 2009\u20132010\u2009cycles of the National Health and Nutrition Examination Survey (NHANES). Weighted multivariable logistic regression, along with subgroup and sensitivity analyses, was conducted to assess the combined influence of PhenoAge acceleration and body mass index (BMI) on psoriasis risk. At baseline, 307 participants were diagnosed with psoriasis. Both PhenoAge\u2010accel and elevated body mass index (BMI) were associated with higher risks of psoriasis. After adjusting for potential confounders, compared to those in the BMI\u2009&lt;\u200925\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    \/PhenoAge\u2010accel &lt;\u20090 group, the odds ratios (95% CIs) were 1.07 (0.52\u20132.20), 1.32 (0.92\u20131.90), and 2.00 (1.44\u20132.77) for psoriasis in the BMI\u2009&lt;\u200925\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    \/PhenoAge\u2010accel \u2265\u20090, BMI\u2009\u2265\u200925\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    \/PhenoAge\u2010accel &lt;\u20090, and BMI\u2009\u2265\u200925\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    \/PhenoAge\u2010accel \u2265\u20090 groups, respectively. The results remain robust across a series of subgroups and sensitivity analysis. In conclusion, accelerated phenotypic age and obesity were synergistically associated with an increased risk of psoriasis.\n                  <\/jats:p>","DOI":"10.1111\/exd.70210","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T04:46:44Z","timestamp":1768625204000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Contribution of Phenotypic Age Acceleration and Body Mass Index to Psoriasis Risk in US Adults"],"prefix":"10.1111","volume":"35","author":[{"given":"Yun\u2010Ni","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Phase I Clinical Research Center Sun Yat\u2010Sen Memorial Hospital, Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang\u2010Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"Internal Medicine\u2010Cardiovascular Department Foshan Sanshui District People's Hospital  Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Li","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sun Yat\u2010Sen Memorial Hospital, Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sun Yat\u2010Sen Memorial Hospital, Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5694-4231","authenticated-orcid":false,"given":"Wen\u2010Qi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermotology Gongli Hospital of Shanghai Pudong New Area  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9008-3912","authenticated-orcid":false,"given":"Wen\u2010Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sun Yat\u2010Sen Memorial Hospital, Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61909-7"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03361.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13854"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18044"},{"issue":"14","key":"e_1_2_11_6_1","first-page":"467","article-title":"Psoriasis as a Systemic Disease","volume":"121","author":"Mrowietz U.","year":"2024","journal-title":"Deutsches 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