{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:44:41Z","timestamp":1790379881980,"version":"4.1.0"},"reference-count":100,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100022600","name":"Wan Fang Hospital","doi-asserted-by":"publisher","award":["115\u2010wf\u2010eva\u201036"],"award-info":[{"award-number":["115\u2010wf\u2010eva\u201036"]}],"id":[{"id":"10.13039\/501100022600","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Currently, there is a lack of reliable laboratory tests for monitoring the severity of psoriasis and evaluating treatment efficacy. The neutrophil\u2010to\u2010lymphocyte ratio (NLR) and platelet\u2010to\u2010lymphocyte ratio (PLR) are novel parameters of systemic inflammation. This study aimed to evaluate the association between NLR, PLR and psoriasis. Databases were systematically searched for studies up to May 2025. Publications meeting any of the following criteria were eligible: (1) comparison of NLR and PLR between psoriasis patients and healthy controls, (2) correlation coefficient of NLR and PLR and Psoriasis Area Severity Index (PASI) score, and (3) NLR and PLR before and after 3\u20134\u2009months of biologic therapies. The pooled results showed that the NLR and PLR were significantly higher in patients with psoriasis than in controls (standardised mean difference [SMD]\u2009=\u20090.645, 95% confidence interval [CI] 0.514\u20130.775; SMD\u2009=\u20090.467, 95% CI 0.304\u20130.630). Both NLR and PLR were significantly correlated with the PASI score (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.214, 95% CI 0.178\u20130.250;\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.161, 95% CI 0.114\u20130.207). The NLR and PLR significantly decreased after receiving tumour necrosis factor\u2010\u03b1 blockers, ustekinumab, and interleukin\u201023 inhibitors for 3\u20134\u2009months. The NLR and PLR may serve as convenient tools in monitoring psoriasis treatment and indicators of systemic inflammation.\n                  <\/jats:p>","DOI":"10.1111\/exd.70214","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:33:22Z","timestamp":1769150002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluating Psoriasis Severity Using the Neutrophil\u2010to\u2010Lymphocyte Ratio and Platelet\u2010to\u2010Lymphocyte Ratio: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1036-9800","authenticated-orcid":false,"given":"Yi\u2010Hsuan","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Dermatology, Wan Fang Hospital Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6479-5634","authenticated-orcid":false,"given":"Pei\u2010Yun","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Wan Fang Hospital Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Chen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Wan Fang Hospital Taipei Medical University  Taipei Taiwan"},{"name":"Research Center of Big Data and Meta\u2010Analysis, Wan Fang Hospital Taipei Medical University  Taipei Taiwan"},{"name":"Department of Dermatology, School of Medicine, College of Medicine Taipei Medical University  Taipei 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