{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:42:31Z","timestamp":1789051351743,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["22K21370"],"award-info":[{"award-number":["22K21370"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["23K24354"],"award-info":[{"award-number":["23K24354"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Systemic sclerosis (SSc) is a systemic autoimmune disease characterised by vasculopathy and fibrosis of the skin and internal organs. In SSc, normal angiogenic processes are impaired due to abnormalities in vascular endothelial cells and pericytes. Nailfold videocapillaroscopy (NVC) is useful for evaluating microvascular injury in SSc. Tocilizumab (TCZ), an anti\u2010IL\u20106 receptor antibody, has demonstrated efficacy in SSc\u2010associated interstitial lung disease (SSc\u2010ILD); however, its effects on vascular abnormalities in SSc remain poorly understood. We evaluated longitudinal changes in NVC findings in 13 SSc patients treated with monthly intravenous TCZ. Capillary density significantly increased at 6\u2009months compared with baseline. This increase was positively and strongly correlated with improvements in pulmonary function test results. To further explore the correlation between NVC findings and angiogenic mediators, we quantified serum levels of seven pivotal angiogenic factors before and 6\u2009months after TCZ initiation using a multiplex immunoassay. Among the angiogenic factors, serum levels of vascular endothelial growth factor (VEGF)\u2010A, platelet endothelial cell adhesion molecule (PECAM)\u20101 and hepatocyte growth factor (HGF) were significantly intercorrelated and significantly decreased after 6\u2009months of treatment. Notably, serum HGF levels showed the strongest correlation with capillary density and were also significantly correlated with modified Rodnan skin score. Furthermore, the decrease in serum VEGF\u2010A levels was robustly associated with improvements in pulmonary function test results. Our results collectively suggest that TCZ treatment is associated with changes in systemic vascular abnormalities and angiogenic factor profiles in SSc, which are critically involved in the pathophysiology of SSc\u2010associated interstitial lung disease.<\/jats:p>","DOI":"10.1111\/exd.70220","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T06:05:12Z","timestamp":1770703512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of the Dynamics of Clinical Parameters and Serum Angiogenic Factors in Systemic Sclerosis Patients Undergoing Tocilizumab Treatment"],"prefix":"10.1111","volume":"35","author":[{"given":"Yuichiro","family":"Segawa","sequence":"first","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai 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