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In early stages, clinical presentation is often indistinguishable from benign chronic inflammatory skin diseases such as atopic dermatitis (AD), posing a challenge for proper diagnosis and treatment. Previous studies have established that MF is characterized by the expansion of a single T\u2010cell clone, whereas benign skin conditions are polyclonal in nature. In this study, we aimed to use single\u2010cell RNA sequencing data to detect distinct transcriptomic features of early\u2010stage MF in comparison to AD skin. In early\u2010stage MF, we observed gene expression differences in cells of both the stroma and the immune system, with keratinocytes exhibiting increased interferon response and proliferation (\n                    <jats:italic>STAT1<\/jats:italic>\n                    ,\n                    <jats:italic>ICAM1<\/jats:italic>\n                    ,\n                    <jats:italic>HLA\u2010DRA<\/jats:italic>\n                    ,\n                    <jats:italic>GJB2<\/jats:italic>\n                    ), while fibroblasts displayed tumour\u2010associated programs (\n                    <jats:italic>CXCL2<\/jats:italic>\n                    ,\n                    <jats:italic>TNFAIP6<\/jats:italic>\n                    ,\n                    <jats:italic>CEBPD<\/jats:italic>\n                    ). Myeloid cells exhibited expression of immunomodulatory genes (\n                    <jats:italic>RUNX3<\/jats:italic>\n                    ,\n                    <jats:italic>DDIT4<\/jats:italic>\n                    ,\n                    <jats:italic>IL4I1<\/jats:italic>\n                    ), and malignant T\u2010cells expressed exhaustion\u2010associated markers (\n                    <jats:italic>CXCL13<\/jats:italic>\n                    ,\n                    <jats:italic>SOCS3<\/jats:italic>\n                    ,\n                    <jats:italic>F2R<\/jats:italic>\n                    ,\n                    <jats:italic>ETV1<\/jats:italic>\n                    ), as opposed to AD and healthy control samples. Thus, our results provide a novel insight into the immune\u2010stroma crosstalk in the tissue microenvironment of early\u2010stage MF vs. AD skin lesions.\n                  <\/jats:p>","DOI":"10.1111\/exd.70240","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:43:23Z","timestamp":1774586603000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Molecular Markers Distinguishing Early\u2010Stage Mycosis Fungoides From Atopic Dermatitis Skin Lesions"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8614-9457","authenticated-orcid":false,"given":"Brandon D.","family":"Ng","sequence":"first","affiliation":[{"name":"Department of Dermatology, Icahn School of Medicine  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor","family":"Whelan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Icahn School of Medicine  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Alkon","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Kurowski","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Icahn School of Medicine  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanze","family":"Jonak","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3488-3345","authenticated-orcid":false,"given":"Patrick M.","family":"Brunner","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Icahn School of Medicine  New York 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