{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:55:46Z","timestamp":1790286946034,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Bullous pemphigoid (BP) induced by immune checkpoint inhibitors (ICI\u2010BP) is a rare immune\u2010related adverse event that affects patient prognosis and management; however, comparative data between ICI\u2010BP and non\u2010ICI BP, especially the dynamic changes of antibodies remain scarce. Therefore, we conducted this study to compare clinical presentation, immunological profile, treatment, management, and outcomes of ICI\u2010BP versus non\u2010ICI BP. This was a retrospective, single\u2010centre cohort study of consecutive patients between 2019 and 2025. Patients with ICI\u2010BP (Group A) were compared with Group B (BP with concurrent malignancy but no ICI exposure) and Group C (classic BP). There were 34, 10, and 68 patients enrolled in Groups A, B, and C, respectively (median follow\u2010up 24.5\u2009months, IQR 10.8\u201350.0). ICI\u2010BP presented at a younger age (median, 59.0\u2009years; IQR, 53.3\u201369.5;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and showed a marked male predominance (88.2%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003). A transient, albeit non\u2010significant, rise in anti\u2010BP180 reactivity was observed during the first 2 months in ICI\u2010BP. Systemic glucocorticoids were required more frequently in ICI\u2010BP, and IL\u20104 inhibitors demonstrated superior potency in accelerating BP180 antibody decline compared to non\u2010systematic therapy. Tumour response rates were similar between Groups A and B, as was mortality across the three groups. In conclusion, ICI\u2010BP differs from non\u2010ICI BP in clinical and immunological features and more often necessitates systemic glucocorticoid therapy, while IL\u20104 inhibitors potentially expedite the reduction of anti\u2010BP180 antibodies in ICI\u2010BP patients.\n                  <\/jats:p>","DOI":"10.1111\/exd.70241","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:47:40Z","timestamp":1774586860000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Immune Checkpoint Inhibitor\u2010Related Bullous Pemphigoid: Distinct Clinical and Immunological Profiles"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7116-5152","authenticated-orcid":false,"given":"Min","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, West China Hospital Sichuan University  Chengdu China"},{"name":"Department of Dermatology &amp; Rare Diseases Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3486-8270","authenticated-orcid":false,"given":"Xun","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, West China Hospital Sichuan University  Chengdu China"},{"name":"Department of Dermatology &amp; Rare Diseases Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jishu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, West China Hospital Sichuan University  Chengdu China"},{"name":"Department of Dermatology &amp; Rare Diseases Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4094-6987","authenticated-orcid":false,"given":"Tong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, West China Hospital Sichuan University  Chengdu China"},{"name":"Department of Dermatology &amp; Rare Diseases Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyuan","family":"Li","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, West China Hospital Sichuan University  Chengdu China"},{"name":"Department of Dermatology &amp; Rare Diseases Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mintong","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, West China Hospital Sichuan University  Chengdu China"},{"name":"Department of Dermatology &amp; Rare Diseases Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, West China Hospital Sichuan University  Chengdu China"},{"name":"Department of Dermatology &amp; Rare Diseases Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, West China Hospital Sichuan University  Chengdu China"},{"name":"Department of Dermatology &amp; Rare Diseases Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, West China Hospital Sichuan University  Chengdu China"},{"name":"Department of Dermatology &amp; Rare Diseases Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3013-9655","authenticated-orcid":false,"given":"Yue","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of 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