{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:57:17Z","timestamp":1790200637510,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021201","name":"European Academy of Dermatology and Venereology","doi-asserted-by":"publisher","award":["PPRC\u20102023\u20100047"],"award-info":[{"award-number":["PPRC\u20102023\u20100047"]}],"id":[{"id":"10.13039\/501100021201","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hidradenitis suppurativa (HS) is an autoinflammatory keratinisation disease affecting the pilosebaceous unit and hallmarked by a complex and multifactorial pathogenesis. Although genomic and transcriptomic investigations have substantially advanced our understanding of key mechanisms underlying HS pathogenesis, proteomic studies remain limited, despite the significant potential of serum proteomics to identify molecular signatures reflecting both cutaneous and systemic inflammatory activity. This exploratory study presents a serum proteomic analysis of patients with moderate\u2010to\u2010severe HS, identifying 306 differentially abundant proteins out of 3153 profiled (FDR\n                    <jats:italic>q<\/jats:italic>\n                    \u2009&lt;\u20090.10). Sensitivity analysis at\n                    <jats:italic>q<\/jats:italic>\n                    \u2009&lt;\u20090.05 (194 proteins) confirmed a robust inflammatory signature, while the FDR\n                    <jats:italic>q<\/jats:italic>\n                    \u2009&lt;\u20090.10 threshold was necessary to preserve markers of epidermal homeostasis, which are inherently diluted in systemic circulation. Enrichment analyses revealed dysregulated pathways related to keratinisation, epidermal differentiation and extracellular matrix (ECM) remodelling, indicating impaired skin barrier function. Concurrent higher abundance of immune\u2010related pathways, including defence response to bacterium, complement activation and neutrophil degranulation, suggest systemic inflammation potentially linked to microbial dysbiosis. These findings suggest the dual role of epithelial dysfunction and autoinflammation in HS pathogenesis. Integration of proteomic data with genomic and transcriptomic findings underscores the value of multi\u2010omics approaches in guiding targeted therapeutic development.\n                  <\/jats:p>","DOI":"10.1111\/exd.70244","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:56:45Z","timestamp":1774612605000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Serum Proteomic Profiling Uncovers Dysregulated Keratinisation and Immune\u2010Related Pathways in Hidradenitis Suppurativa"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0060-5870","authenticated-orcid":false,"given":"Chiara","family":"Moltrasio","sequence":"first","affiliation":[{"name":"Dermatology Unit Fondazione IRCCS ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5829-3971","authenticated-orcid":false,"given":"Sara","family":"Roncar\u00e0","sequence":"additional","affiliation":[{"name":"Pediatric Department Institute for Maternal and Child Health \u2013 IRCCS Burlo Garofolo  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2669-439X","authenticated-orcid":false,"given":"Blendi","family":"Ura","sequence":"additional","affiliation":[{"name":"Maternal\u2010Neonatal Department Institute for Maternal and Child Health \u2010 IRCCS Burlo Garofolo  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8655-9393","authenticated-orcid":false,"given":"Elena Maria","family":"Nardacchione","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical and Health Sciences University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8654-6431","authenticated-orcid":false,"given":"Eduardo","family":"Sommella","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Salerno  Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8730-9948","authenticated-orcid":false,"given":"Ronald","family":"Moura","sequence":"additional","affiliation":[{"name":"Department of Advanced Diagnostics Institute for Maternal and Child Health \u2010 IRCCS Burlo Garofolo  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Derlino","sequence":"additional","affiliation":[{"name":"Dermatology Unit Fondazione IRCCS ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2258-8357","authenticated-orcid":false,"given":"Angelo Valerio","family":"Marzano","sequence":"additional","affiliation":[{"name":"Dermatology Unit Fondazione IRCCS ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Pathophysiology and Transplantation Universit\u00e0 Degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8493-1168","authenticated-orcid":false,"given":"Sergio","family":"Crovella","sequence":"additional","affiliation":[{"name":"Department of Environmental and Prevention Science University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1954-4126","authenticated-orcid":false,"given":"Paola Maura","family":"Tricarico","sequence":"additional","affiliation":[{"name":"Pediatric Department Institute for Maternal and Child Health \u2013 IRCCS Burlo Garofolo  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022\u201006"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.02.003"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)02475\u20109"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.3630"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10082039"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2024.11.019"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2023.221"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.11.050"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12101371"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26167704"},{"key":"e_1_2_12_12_1","first-page":"729","volume-title":"Dermatologic Surgery","author":"Hurley H. 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