{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:39:03Z","timestamp":1776872343811,"version":"3.51.2"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Segmental vitiligo (SV) is a distinct subtype of vitiligo characterized by an early onset, unilateral distribution, and rapid stabilization. Although traditionally considered neurogenic in origin, recent evidence suggests an immune\u2010mediated pathomechanism. However, the molecular mechanisms underlying SV remain poorly characterized, and therapeutic options are limited. Topical calcineurin inhibitors (TCI) are widely used in immune\u2010mediated dermatoses, but clinical data supporting their use in SV are scarce. We conducted a retrospective observational study of paediatric patients with SV treated with TCI, recording demographics, disease duration and 3\u2010month clinical response. In parallel, selected public transcriptomic datasets were re\u2010analysed to examine enrichment of TCR\/Ca2\u2009+\u2009\u2212calcineurin\/NFAT\u2010related pathways as supportive mechanistic context. Five of eight patients (62.5%) achieved significant repigmentation (VNS \u2265\u20094) after 12\u2009weeks, with shorter disease duration correlating with better outcomes (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0002451). Early intervention determined good clinical response even in cases with leukotrichia, and no adverse effects were observed. Transcriptomic re\u2010analysis provided supportive, descriptive signals consistent with activation of T\u2010cell signalling and Ca2\u2009+\u2009\u2212calcineurin\/NFAT pathways in SV blood, while proxy datasets from non\u2010segmental vitiligo skin did not show similar enrichment. Overall, in this small retrospective paediatric case series, early use of topical calcineurin inhibitors was associated with favourable clinical outcomes in SV and demonstrated a good safety profile. Larger, prospective studies are warranted to confirm these preliminary findings and refine therapeutic strategies.\n                  <\/jats:p>","DOI":"10.1111\/exd.70248","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:14:41Z","timestamp":1775276081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Intervention with Calcineurin Inhibitors in Paediatric Segmental Vitiligo: A Retrospective Case Series"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0916-7769","authenticated-orcid":false,"given":"Alessia","family":"Paganelli","sequence":"first","affiliation":[{"name":"Centro di Dermatologia Rigenerativa Ed Immunologica (CEDRI) IDI\u2010IRCCS Istituto Dermopatico dell'Immacolata  Rome Italy"},{"name":"Department of Life Science, Health, and Health Professions Link Campus University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni Luca","family":"Scaglione","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit IDI\u2010IRCCS Istituto Dermopatico dell'Immacolata  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito Giuseppe","family":"Di Lernia","sequence":"additional","affiliation":[{"name":"UOC di Dermatologia AUSL\u2010IRCCS di Reggio Emilia  Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iria","family":"Neri","sequence":"additional","affiliation":[{"name":"UOC di Dermatologia Policlinico S. Orsola  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Corrente","sequence":"additional","affiliation":[{"name":"Cell and Molecular Biology Lab  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Picardo","sequence":"additional","affiliation":[{"name":"Centro di Dermatologia Rigenerativa Ed Immunologica (CEDRI) IDI\u2010IRCCS Istituto Dermopatico dell'Immacolata  Rome Italy"},{"name":"UniCamillus Saint Camillus University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.11.061"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60763-7"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163806"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.11"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.25259\/CSDM_168_2023"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1999.tb02067.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-69361-1_5"},{"issue":"1","key":"e_1_2_12_9_1","first-page":"61","article-title":"Leucotrichia and Segmental Vitiligo","volume":"26","author":"Tagliavanti M.","year":"2016","journal-title":"European Journal of Pediatric 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