{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:08:07Z","timestamp":1791976087129,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Obesity reduces response to biologic therapy in psoriasis, but comparative evidence across drug classes in Chinese patients is limited. A real\u2010world cohort of 891 adults with moderate\u2010to\u2010severe psoriasis initiating biologics between 2020 and 2025 was divided by baseline BMI (&lt;\u200924 vs. \u2265\u200924\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ). PASI90 achievement at 2, 4, 6 and 12\u2009months and drug survival were compared amongst IL\u201017, IL\u201023 and TNF\u2010\u03b1 inhibitors. Amongst IL\u201017 users, PASI90 rates in the non\u2010overweight group were consistently higher at 4, 6 and 12\u2009months (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), whereas no BMI\u2010related differences were seen with TNF\u2010\u03b1 or IL\u201023 blockade. Within the non\u2010overweight stratum, IL\u201017 and IL\u201023 agents outperformed TNF\u2010\u03b1 inhibitors at month 6 and yielded fewer switches (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). In the overweight\/obese stratum, IL\u201023 blockade achieved the highest PASI90 rates and longest drug survival versus both IL\u201017 and TNF\u2010\u03b1 inhibitors (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). In this real\u2010world cohort of Chinese psoriasis patients, BMI was observed to correlate with biologic effectiveness in a drug\u2010specific manner. Our findings suggest that whilst IL\u201017 or IL\u201023 inhibitors showed favourable outcomes for non\u2010overweight individuals, IL\u201023 blockade may be associated with a more sustained response in those categorised as overweight or obese.\n                  <\/jats:p>","DOI":"10.1111\/exd.70252","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T09:40:27Z","timestamp":1776073227000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biologic Efficacy by\n                    <scp>BMI<\/scp>\n                    in Moderate\u2010To\u2010Severe Psoriasis: A Real\u2010World Cohort Study"],"prefix":"10.1111","volume":"35","author":[{"given":"Xin","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Dermatology, Xijing Hospital Fourth Military Medical University  Xi'an Shaanxi 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