{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T04:57:36Z","timestamp":1780981056024,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102021R1F1A1059510"],"award-info":[{"award-number":["NRF\u20102021R1F1A1059510"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102026\u201025478813"],"award-info":[{"award-number":["RS\u20102026\u201025478813"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Benzo[\n                    <jats:italic>a<\/jats:italic>\n                    ]pyrene (BaP), a polycyclic aromatic hydrocarbon and environmental pollutant, has been implicated in the exacerbation of psoriasis, although the underlying molecular mechanisms remain unclear. In this study, we investigated the role of BaP in inflammation, focusing on serum exosomes, using a mouse model of imiquimod (IMQ)\u2010induced psoriasis. Topical BaP exposure aggravated psoriatic skin inflammation and increased the expression of aryl hydrocarbon receptor (AhR), CYP1A1, and proinflammatory cytokines in lesional skin. Serum exosomes from BaP\u2009+\u2009IMQ\u2010treated mice enhanced cytokine expression in primary mouse keratinocytes. High\u2010throughput miRNA profiling revealed that 81 and 91 miRNAs were upregulated in serum exosomes from IMQ\u2010 and BaP\u2009+\u2009IMQ\u2010treated mice, respectively, compared to controls. Notably, mmu\u2010miR\u2010423\u20103p was the most upregulated in both groups, as validated by quantitative reverse transcription\u2013polymerase chain reaction (qRT\u2010PCR). Consistently, hsa\u2010miR\u2010423\u20105p was significantly elevated in circulating exosomes from psoriasis patients compared to healthy controls, confirmed by miRNA sequencing and qRT\u2010PCR. KEGG pathway analysis linked hsa\u2010miR\u2010423\u20105p to the MAPK signalling pathway. Functionally, miR\u2010423\u20105p triggered an increase in the expression of pro\u2010inflammatory cytokines and oxidative stress in psoriatic keratinocytes. These findings suggest that BaP exacerbates psoriatic inflammation via AhR signalling and that serum exosomal miR\u2010423 may serve as a biomarker for environmentally induced psoriasis exacerbation.\n                  <\/jats:p>","DOI":"10.1111\/exd.70267","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:05:26Z","timestamp":1778735126000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Benzo[\n                    <i>a<\/i>\n                    ]pyrene Aggravates Psoriasis\u2010Like Skin Inflammation via Circulating Exosomal\n                    <scp>microRNA<\/scp>\n                    Modulation"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7519-8910","authenticated-orcid":false,"given":"Hye Ran","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology, Kangnam Sacred Heart Hospital Hallym University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2872-8215","authenticated-orcid":false,"given":"Jin Seo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kangnam Sacred Heart Hospital Hallym University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5846-0008","authenticated-orcid":false,"given":"Hye One","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kangnam Sacred Heart Hospital Hallym University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Wook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kangnam Sacred Heart Hospital Hallym University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2795-0140","authenticated-orcid":false,"given":"Bo Young","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kangnam Sacred Heart Hospital Hallym University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx300043k"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2014.01.028"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10937404.2022.2164390"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.171492"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.07.004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljac124"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14910"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.6019"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12670"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.11.014"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475415616073"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520964024"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae130"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-101512-122326"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-019-0282-2"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18030538"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.01.059"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.895564"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S439760"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq033"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3715"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa970"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2017.08.003"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.15166"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.117065"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101530"},{"issue":"1","key":"e_1_2_10_31_1","first-page":"42","article-title":"An Environmental Contaminant, Benzo(a)pyrene, Induces Oxidative Stress\u2010Mediated Interleukin\u20108 Production in Human Keratinocytes via the Aryl Hydrocarbon Receptor Signaling Pathway","volume":"62","author":"Tsuji G.","year":"2011","journal-title":"Journal of Dermatological Science"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.04.019"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.12.013"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.02.020"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2023.1324692"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01655-6"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/569751"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22175"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.4110\/in.2011.11.3.135"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-009-8070-5"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-024-05080-3"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-022-00942-1"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-021-01352-4"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10102636"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8030201"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/13685538.2019.1597840"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23102"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-018-1879-8"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.70267","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.70267","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.70267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T04:04:03Z","timestamp":1780977843000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.70267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/exd.70267"],"URL":"https:\/\/doi.org\/10.1111\/exd.70267","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-06-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70267"}}