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Although Mendelian randomization (MR) studies have been widely applied to investigate its potential risk factors, existing evidence remains fragmented and sometimes contradictory, limiting clinical translation. This study aimed to systematically consolidate MR findings on psoriasis and to develop an interactive online platform to support clinical decision\u2010making. We systematically searched PubMed, Embase, and Web of Science for psoriasis\u2010related MR studies published up to December 31, 2025, and performed a structured organization and evidence synthesis of the eligible studies. We also developed the MR\u2010PsO Atlas platform using R and Shiny, integrating evidence retrieval, comparative analysis, and exploratory meta\u2010integration where basic comparability was met. A total of 346 MR articles were included, from which 1046 causal associations were extracted. Overall, the findings support an association between disrupted lipid metabolism\u2014particularly elevated LDL\u2010C and certain phospholipid species\u2014and increased psoriasis risk. The results also suggest possible causal links between psoriasis and psychiatric conditions such as depression, and identify IFNLR1 and APOF as potential novel therapeutic targets. For controversial findings, including those related to blood lipids and cancer risk, we further evaluated directional consistency across studies through exploratory meta\u2010integration and discussion of heterogeneity. In addition, the MR\u2010PsO Atlas platform has been successfully deployed and is openly accessible for the retrieval, comparison, and visualization of causal evidence. This study systematically collated published MR evidence on psoriasis and constructed a corresponding evidence atlas to support the retrieval, comparison and interpretation of causal findings. The results highlight multidimensional pathogenic mechanisms ranging from metabolism to immunity. The MR\u2010PsO Atlas platform provides a practical tool for integrating genetic evidence with clinical practice and may help advance precision prevention and management of psoriasis.<\/jats:p>","DOI":"10.1111\/exd.70272","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T06:55:08Z","timestamp":1779260108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mapping the Causal Landscape of Psoriasis: A Systematic Mendelian Randomization Evidence Synthesis and Development of the\n                    <scp>MR<\/scp>\n                    \u2010\n                    <scp>PsO<\/scp>\n                    Atlas Platform"],"prefix":"10.1111","volume":"35","author":[{"given":"Jin\u2010Yu","family":"Lu","sequence":"first","affiliation":[{"name":"Dongguan Hospital of Guangzhou University of Chinese Medicine, Dongguan Traditional Chinese Medicine Hospital  Dongguan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenling","family":"Zeng","sequence":"additional","affiliation":[{"name":"The Second Clinical School, Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Clifford Hospital, Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junlin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Pan","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9971-4489","authenticated-orcid":false,"given":"Qiaoming","family":"Fan","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyi","family":"Yang","sequence":"additional","affiliation":[{"name":"Clinical Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manting","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8433-980X","authenticated-orcid":false,"given":"Kai\u2010Fang","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dongguan Hospital of Guangzhou University of Chinese Medicine, Dongguan Traditional Chinese Medicine Hospital  Dongguan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01261.x"},{"issue":"2","key":"e_1_2_13_3_1","first-page":"187","article-title":"Prevalence of Psoriasis in Children and Adolescents in the United States: A Claims\u2010Based Analysis","volume":"17","author":"Paller A. 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