{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:00:33Z","timestamp":1790611233454,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The relapse of psoriasis precludes a complete cure and can result in multisystem comorbidities, making relapse prevention a critical clinical challenge. Clinically, psoriasis tends to worsen or relapse in winter, but the underlying mechanisms remain unclear. In this study, we utilized an imiquimod (IMQ)\u2010induced psoriasis\u2010like mouse model to investigate the role of cold stress in the exacerbation of psoriasis during winter. Our data indicate that cold stress significantly aggravates IMQ\u2010induced psoriatic lesions. While cold stress alone does not directly induce psoriasis, it can promote the development of psoriasis\u2010like lesions in mice exposed to low doses of IMQ. Single\u2010nucleus transcriptome analysis demonstrated that cold stress leads to the remodelling of macrophage phenotypes in psoriatic lesions, with a notable increase in ACSL1+\u2009macrophages. These cells exhibit higher intracellular neutral lipid content and produce more IL\u20101\u03b2, which in turn stimulates \u03b3\u03b4T cells to secrete more IL\u201017A. The increase of ACSL1+ macrophages is associated with cold stress\u2013induced lipid synthesis in dermal adipocytes. Notably, the number of ACSL1+ IL\u20101\u03b2\u2009+\u2009macrophages is significantly increased in the skin of psoriasis patients in winter. Therefore, targeting the formation of ACSL1+ macrophages may be a potential strategy to prevent the worsening of psoriasis in winter.<\/jats:p>","DOI":"10.1111\/exd.70280","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:41:52Z","timestamp":1780386112000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cold Stress Activates\n                    <scp>ACSL1<\/scp>\n                    + Macrophages in a Fatty Acid\u2010Dependent Manner to Exacerbate Psoriasis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9003-029X","authenticated-orcid":false,"given":"Ce","family":"Shuai","sequence":"first","affiliation":[{"name":"Department of Dermatology, Ruijin Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai 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