{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:04:55Z","timestamp":1785434695579,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hair loss is a common condition with limited therapeutic options, and bacterial extracellular vesicles have recently emerged as potential bioactive mediators in skin biology. Here, we investigated whether an extracellular vesicle\u2010enriched preparation obtained from\n                    <jats:italic>Sphingomonas olei<\/jats:italic>\n                    , a bacterium isolated from healthy human skin (hereafter SoEVs), influences human hair\u2010growth\u2010related responses and whether these effects are associated with Wnt\/\u03b2\u2010catenin\u2010related signalling. SoEVs were non\u2010cytotoxic to human dermal papilla (DP) cells and upregulated the hair\u2010growth\u2010related factors\n                    <jats:italic>IGF1<\/jats:italic>\n                    and\n                    <jats:italic>VEGFA<\/jats:italic>\n                    . In DP cells, SoEV treatment was accompanied by increased levels of phosphorylated AKT and GSK\u20103\u03b2, and total \u03b2\u2010catenin, alongside the induction of canonical Wnt readouts\n                    <jats:italic>LEF1<\/jats:italic>\n                    and\n                    <jats:italic>AXIN2<\/jats:italic>\n                    . In ex\u00a0vivo cultured human hair follicles, SoEVs promoted hair shaft elongation, counteracted shaft thinning and increased the number of Ki\u201067\u2013positive cells around the DP. Together, these findings suggest that SoEVs may support human hair\u2010growth\u2010related responses in association with Wnt\/\u03b2\u2010catenin\u2010related signalling, warranting further mechanistic and in\u00a0vivo investigation.\n                  <\/jats:p>","DOI":"10.1111\/exd.70284","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T05:13:27Z","timestamp":1781846007000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Sphingomonas olei<\/i>\n                    Extracellular Vesicles Promote Hair\u2010Growth Responses Linked to Wnt\/\u03b2\u2010Catenin Signalling"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0866-3130","authenticated-orcid":false,"given":"Eunyoung","family":"Seo","sequence":"first","affiliation":[{"name":"CutisBio Co., Ltd  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2738-9517","authenticated-orcid":false,"given":"Minji","family":"Park","sequence":"additional","affiliation":[{"name":"CutisBio Co., Ltd  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaeeun","family":"Lee","sequence":"additional","affiliation":[{"name":"CutisBio Co., Ltd  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Mi","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University Bundang Hospital  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7250-5209","authenticated-orcid":false,"given":"Jang\u2010Hee","family":"Oh","sequence":"additional","affiliation":[{"name":"Laboratory of Cutaneous Aging Research, Biomedical Research Institute Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon\u2010Woo","family":"Noh","sequence":"additional","affiliation":[{"name":"Maxwell Hair Transplant Clinic  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2331-7305","authenticated-orcid":false,"given":"Won\u2010Woo","family":"Choi","sequence":"additional","affiliation":[{"name":"CutisBio Co., Ltd  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.1.449"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02793"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(01)02027-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12030893"},{"issue":"6","key":"e_1_2_9_6_1","first-page":"371","article-title":"Hair Loss: Common Causes and Treatment","volume":"96","author":"Phillips T. 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