{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:07:46Z","timestamp":1785434866369,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404152"],"award-info":[{"award-number":["82404152"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2023209084"],"award-info":[{"award-number":["H2023209084"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Psoriasis is a recurrent autoimmune disease. No biological factor that is associated with the risk of psoriasis has been definitively identified. The potential role of the immunogen double\u2010stranded (ds)DNA as a trigger of and biomarker for psoriasis warrants exploration. This multicentre case\u2013control study included 3 069 patients with psoriasis and 7 041 healthy controls from 12 regions in China. The associations of the serum dsDNA level with the psoriasis risk and severity were analysed in the overall population. The serum dsDNA level was significantly higher in patients than in controls. Each 0.1\u2009ng\/mL increase in serum dsDNA was significantly associated with increased odds of psoriasis (adjusted odds ratio, 1.45; 95% confidence interval, 1.40\u20131.48;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). The optimal serum dsDNA cutoff value for the diagnosis of psoriasis was 1.11\u2009ng\/mL, with 61.6% sensitivity and 74.8% specificity. A significant dose\u2013response relationship was observed between the serum dsDNA level and the risk of psoriasis\u2010associated morbidity when using the optimal dsDNA cutoff value as the reference. Serum dsDNA levels were positively associated with higher PASI and BSA scores and the severity of psoriasis. These findings suggest that serum dsDNA level is strongly associated with psoriasis morbidity and severity.\n                  <\/jats:p>","DOI":"10.1111\/exd.70291","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:59:14Z","timestamp":1781917154000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum\n                    <scp>DSDNA<\/scp>\n                    is Associated With Psoriasis"],"prefix":"10.1111","volume":"35","author":[{"given":"Qi","family":"Zhen","sequence":"first","affiliation":[{"name":"North China University of Science and Technology Affiliated Hospital  Thangshan China"},{"name":"Health Science Center North China University of Science and Technology  Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Yin","sequence":"additional","affiliation":[{"name":"North China University of Science and Technology Affiliated Hospital  Thangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Chen","sequence":"additional","affiliation":[{"name":"North China University of Science and Technology Affiliated Hospital  Thangshan China"},{"name":"Health Science Center North China University of Science and Technology  Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangbo","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyun","family":"Yan","sequence":"additional","affiliation":[{"name":"North China University of Science and Technology Affiliated Hospital  Thangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yirui","family":"Wang","sequence":"additional","affiliation":[{"name":"North China University of Science and Technology Affiliated Hospital  Thangshan China"},{"name":"Health Science Center North China University of Science and Technology  Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Li","sequence":"additional","affiliation":[{"name":"North China University of Science and Technology Affiliated Hospital  Thangshan China"},{"name":"Health Science Center North China University of Science and Technology  Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingxue","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Dermatology at No. 2 Hospital Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhi","family":"Lv","sequence":"additional","affiliation":[{"name":"Dalian Dermatosis Hospital  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Wuhan Special Service Recuperation Center  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaqing","family":"Hu","sequence":"additional","affiliation":[{"name":"Health Management Center, No. 1 Hospital Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qijun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Donggang Center Hospital  Dandong Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8484-2314","authenticated-orcid":false,"given":"Xiaojing","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Dermatology People's Hospital of Xinjiang Uygur Autonomous Region  Xinjiang Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory at No. 1 Hospital Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7159-879X","authenticated-orcid":false,"given":"Yan","family":"Lu","sequence":"additional","affiliation":[{"name":"Dermatology Department of the First Affiliated Hospital Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology People's Hospital of Xinjiang Uygur Autonomous Region  Xinjiang Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3504-1630","authenticated-orcid":false,"given":"Song","family":"Wu","sequence":"additional","affiliation":[{"name":"Urology Institute of Shenzhen University, the Luohu Affiliated Hospital of Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Guangdong Medical University  Zhanjiang Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology at Chengdu Second People's Hospital  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5856-4584","authenticated-orcid":false,"given":"Ruiqun","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Hospital of China Medical University  Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology The First Affiliated Hospital Of Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Affiliated Hospital of Inner Mongolia Medical University  Hohhot China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Dermatology at Chengdu Second People's Hospital  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihai","family":"Shi","sequence":"additional","affiliation":[{"name":"Dermatology at the First Affiliated Hospital of Baotou Medical College  Baotou Inner Mongolia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jining No. 1 People's Hospital  Jining Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Guangdong Medical University  Zhanjiang Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology at No. 1 Hospital of Jilin University  Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2175-5782","authenticated-orcid":false,"given":"Fuqiu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology at No. 2 Hospital Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8809-8564","authenticated-orcid":false,"given":"XingHua","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Hospital of China Medical University  Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2874-7013","authenticated-orcid":false,"given":"Yang","family":"Han","sequence":"additional","affiliation":[{"name":"North China University of Science and Technology Affiliated Hospital  Thangshan China"},{"name":"Health Science Center North China University of Science and Technology  Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8499-5353","authenticated-orcid":false,"given":"Liangdan","family":"Sun","sequence":"additional","affiliation":[{"name":"North China University of Science and Technology Affiliated Hospital  Thangshan China"},{"name":"Health Science Center North China University of Science and Technology  Tangshan China"},{"name":"Department of Dermatology The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education  Hefei China"},{"name":"School of Public Health North China University of Science and Technology  Tangshan Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61909-7"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22260"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.05.004"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.54"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat1022"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7793"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00882"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1116706108"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba4823"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.145395"},{"key":"e_1_2_11_13_1","volume-title":"Global Solar UV Index: A Practical Guide","author":"WHO","year":"2002"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8665351"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.10.004"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.1198"},{"key":"e_1_2_11_17_1","volume-title":"Global Report on Psoriasis","year":"2016"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.008"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13542"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2007.08.003"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06502.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113215"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.08.015"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.46"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.06.010"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07725"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13041"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.70291","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.70291","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.70291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:52:18Z","timestamp":1785433938000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.70291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/exd.70291"],"URL":"https:\/\/doi.org\/10.1111\/exd.70291","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70291"}}