{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:07:30Z","timestamp":1785434850917,"version":"3.56.0"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Dysregulated type I interferon (IFN\u2010I) signalling is implicated in the pathogenesis of several systemic autoimmune conditions, collectively termed type I interferonopathies. Emerging evidence suggests that aberrant IFN\u2010I pathway activity may similarly contribute to certain autoimmune dermatoses, namely granuloma annulare (GA), lichen planus (LP), cutaneous sarcoidosis (CS) and morphea. We sought to investigate this association using large, real\u2010world cohorts, with type I interferonopathies serving as proxies for IFN\u2010I\u2010driven inflammation. Four retrospective cohort studies were conducted in parallel using the TriNetX Global Collaborative Network. Patients with systemic lupus erythematosus (SLE), systemic sclerosis (SSc), Sjogren's disease (SjD) and dermatomyositis (DM) were 1:1 propensity score\u2010matched to healthy controls (HCs), and relative risks (RRs) for developing GA, CS, LP and morphea were calculated. Sensitivity analyses compared each interferonopathy cohort to patients with gout and ankylosing spondylitis, rheumatologic conditions not mediated by IFN\u2010I pathways. Increased risk of morphea and LP was observed across all four interferonopathy cohorts relative to HCs. Patients with SLE, SSc and SjD had an increased risk of developing CS. GA risk was significantly increased only among patients with SLE and DM. Sensitivity analyses were broadly corroborative. These findings reveal consistent associations between type I interferonopathies and subsequent development of LP, CS and morphea. The results of these analyses are hypothesis\u2010generating and complement existing evidence of an IFN\u2010I mediated pathogenesis for these dermatoses. Prospective studies employing large, representative cohorts paired with transcriptomic and proteomic technologies for mechanistic confirmation are warranted.<\/jats:p>","DOI":"10.1111\/exd.70295","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T06:14:37Z","timestamp":1781072077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Type I Interferonopathies and the Development of Cutaneous Sarcoidosis, Morphea, Lichen Planus and Granuloma Annulare: A Retrospective Cohort Study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2802-6969","authenticated-orcid":false,"given":"Brandon","family":"Block","sequence":"first","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaanvi","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Soto\u2010Canetti","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Ponce Health Sciences University  Ponce Puerto Rico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riley","family":"Spingler","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0882-8163","authenticated-orcid":false,"given":"Benjamin","family":"Ungar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Talia","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2018.11.022"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010020\u201008798\u20102"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.11.031"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2007.04.015"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100625.2012.01475.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.36141\/svdld.v35i1.5793"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2025.04.043"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/sja.SJA_543_18"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001885"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16\u20102607"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20104632.2010.04728.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12021"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.06.013"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000346244"},{"issue":"5","key":"e_1_2_11_16_1","first-page":"863","article-title":"Cutaneous Sarcoidosis in a Woman With Chronic Hepatitis C and Interferon Therapy: A Case Report","volume":"54","author":"Song K.","year":"2010","journal-title":"Acta Cytologica"},{"issue":"9","key":"e_1_2_11_17_1","first-page":"870","article-title":"Concurrent Antiphospholipid Syndrome and Cutaneous [Corrected] Sarcoidosis due to Interferon Alfa and Ribavirin Treatment for Hepatitis C","volume":"8","author":"Shinohara M. 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