{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:06:41Z","timestamp":1785434801213,"version":"3.56.0"},"reference-count":109,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Vagus nerve stimulation (VNS) modulates systemic inflammation through the cholinergic anti\u2010inflammatory pathway, but its effects on cutaneous inflammatory diseases remain unexplored. We investigated whether invasive VNS could reduce clinical inflammation and proinflammatory cytokines in murine models of psoriasis and atopic dermatitis (AD). C57BL\/6 mice received imiquimod 5% cream to induce psoriasiform inflammation, while NC\/Nga mice received 2,4\u2010dinitrochlorobenzene (DNCB) to induce AD\u2010like inflammation. Acute invasive VNS (5\u2009Hz\/5\u2009ms for 5\u2009min) or sham procedures were performed 6 or 24\u2009h before sacrifice. Cutaneous cytokine levels were assessed by immunoblotting and immunofluorescence staining, while systemic inflammation was evaluated by analyzing splenic and plasma cytokines. VNS reduced TNF\u2010\u03b1 and IL\u20106 in imiquimod\u2010treated skin at both 6\u2010 and 24\u2010h post\u2010stimulation (TNF\u2010\u03b1\/6\u2009h: 63%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01; IL\u20106\/6\u2009h: 63%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01; TNF\u2010\u03b1\/24\u2009h: 69%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001; IL\u20106\/24\u2009h: 60%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). In DNCB\u2010treated skin, VNS decreased TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106 at 24\u2009h post\u2010stimulation (TNF\u2010\u03b1\/24\u2009h: 68%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001; IL\u20101\u03b2\/24\u2009h: 48%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05; IL\u20106\/24\u2009h: 66%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). VNS altered cutaneous CD11b\u2010positive macrophage distribution patterns and reduced splenic cytokine levels (TNF\u2010\u03b1 and IL\u20101\u03b2) in the psoriasis model (TNF\u2010\u03b1\/6\u2009h: 73%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001; 24\u2009h: 46%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) (IL\u20101\u03b2\/6\u2009h: 48%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01; 24\u2009h: 41%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) while plasma TNF\u2010\u03b1 decreased in the AD model (24\u2009h: 32%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). This study provides the first evidence that VNS reduces proinflammatory cytokines in inflammatory skin diseases, supporting clinical translation for dermatological applications.\n                  <\/jats:p>","DOI":"10.1111\/exd.70297","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T05:27:02Z","timestamp":1781242022000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vagus Nerve Stimulation Reduces Cutaneous Inflammation and Proinflammatory Cytokines in Murine Models of Psoriasis and Atopic Dermatitis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2335-8780","authenticated-orcid":false,"given":"William J.","family":"Nahm","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida USA"},{"name":"NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki\u2010Joong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Korean Medicine, Institute of Bioscience and Integrative Medicine Daejeon University  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eui","family":"Namgung","sequence":"additional","affiliation":[{"name":"Department of Physics University of California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunha","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Korean Medicine, Institute of Bioscience and Integrative Medicine Daejeon University  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2292-2017","authenticated-orcid":false,"given":"Vincent","family":"Falanga","sequence":"additional","affiliation":[{"name":"Department of Dermatology Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Department of Biochemistry &amp; Cell Biology Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2010.02321.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01321"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000259381.56526.96"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.136"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2873"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-030409-101323"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25307"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01440.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/35013070"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2566"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102796.2004.01442.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02396-z"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42234\u2010021\u201000069\u20105"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1367295"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.03.025"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1173987"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-024-01245-4"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4477"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42234\u2010022\u201000100\u20103"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40473\u2010014\u20100010\u20105"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12541"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.51.1.48"},{"issue":"6","key":"e_1_2_10_24_1","first-page":"S3","article-title":"Therapeutic Mechanisms of Vagus Nerve Stimulation","volume":"59","author":"Henry T. 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