{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:08:02Z","timestamp":1785434882224,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC2151\u2010390873048"],"award-info":[{"award-number":["EXC2151\u2010390873048"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01AR075111"],"award-info":[{"award-number":["K01AR075111"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Alopecia areata (AA) is a common T\u2010cell mediated autoimmune disorder, which leads to sudden, non\u2010scarring hair loss. An association between hair pigmentation and AA pathogenesis has long been postulated. Recent epidemiological evidence supports this link, indicating that individuals with darker hair colours have a higher risk of AA, while those with lighter hair colours exhibit a lower risk. This study aimed to investigate whether a shared genetic basis between hair colour determination and AA risk underlies this observation. To explore this, we analysed data from our AA genome\u2010wide association study (GWAS) of 16\u2009310 Caucasians from the US and Central Europe and a recently published GWAS of hair colour that involved 343\u2009234 UK Biobank participants. Genetic correlations between the two traits were investigated using both polygenic risk score and linkage disequilibrium score regression (LDSC) analyses. No evidence was found for a strong, broadly shared genetic component for hair colour and AA. However, a suggestive weak inverse association with genetically predicted blond hair and AA risk was observed. Given the modest sample size of the AA\u2010GWAS (~4100 cases), these findings are likely underpowered and should be interpreted as exploratory and hypothesis\u2010generating, warranting replication in larger, independent cohorts.<\/jats:p>","DOI":"10.1111\/exd.70299","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:09:21Z","timestamp":1781762961000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Do Alopecia Areata and Hair Colour Have a Shared Genetic\u00a0Component?"],"prefix":"10.1111","volume":"35","author":[{"given":"Leonie","family":"Rieger\u2010Molitor","sequence":"first","affiliation":[{"name":"Institute of Human Genetics University of Bonn, Medical Faculty &amp; University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Maj","sequence":"additional","affiliation":[{"name":"Institute for Genomic Statistics and Bioinformatics University of Bonn, Medical Faculty &amp; University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Redler","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University of Bonn, Medical Faculty &amp; University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmina","family":"Gossmann","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University of Bonn, Medical Faculty &amp; University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Ripke","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Charit\u00e9 \u2013 Universit\u00e4tsmedizin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1573-1653","authenticated-orcid":false,"given":"Lynn","family":"Pethukova","sequence":"additional","affiliation":[{"name":"Ronald O. Perlemen Department of Dermatology NYU Langone Health  New York New York USA"},{"name":"Department of Population Health NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Christiano","sequence":"additional","affiliation":[{"name":"Department of Population Health NYU Langone Health  New York New York USA"},{"name":"Department of Genetics and Development Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus M.","family":"N\u00f6then","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University of Bonn, Medical Faculty &amp; University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6411-4275","authenticated-orcid":false,"given":"F. Buket","family":"Basmanav","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University of Bonn, Medical Faculty &amp; University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina C.","family":"Betz","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics University of Bonn, Medical Faculty &amp; University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.11"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.04.004"},{"key":"e_1_2_11_4_1","first-page":"541","article-title":"Is Alopecia Areata an Autoimmune\u2010Response Against Melanogenesis\u2010Related Proteins, Exposed by Abnormal MHC Class I Expression in the Anagen Hair Bulb?","volume":"66","author":"Paus R.","year":"1993","journal-title":"Yale Journal of Biology and Medicine"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jisp.2020.04.002"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.890027"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.57.4.354"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-006-0668-y"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1978.01640230086031"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03584.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.12.047"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2014.40956"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-022-08954-w"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1984.tb07461.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2007.00390.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120604"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-024-01218-9"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12584237"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6966"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09114"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.185"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.11.008"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj1541"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.123579"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07691-z"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3406"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giz082"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-020-00742-5"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.70299","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.70299","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.70299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:52:03Z","timestamp":1785433923000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.70299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/exd.70299"],"URL":"https:\/\/doi.org\/10.1111\/exd.70299","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70299"}}