{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:50:40Z","timestamp":1787323840341,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Dermal adipocytes have unique features different from visceral and subcutaneous adipocytes. Their cyclic remodelling is coupled with hair follicle (HF) cycling: expansion in the anagen and reduction in the catagen stages. Secreted Ly6\/uPAR related protein 2 (SLURP2) is a non\u2010neuronal transmitter and a ligand of both nicotinic and muscarinic acetylcholine receptors. It is upregulated in psoriatic lesions. Mouse\n                    <jats:italic>SLURP2<\/jats:italic>\n                    \u2010deficient mice exhibit reduced adiposity and plasma cholesterol levels, in addition to palmoplantar keratoderma. However, the effects of SLURP2 on adipocytes remain unexplored. Here, we demonstrated that SLURP2 regulates murine dermal adipocyte size independently of HF cycling and upregulates interleukin (IL)\u201023 gene expression following intradermal injection of recombinant human SLURP2\u2010Fc protein (rSLURP2) and phosphate\u2010buffered saline (control) at different dorsal sites of C57BL\/6J mice after depilation. SLURP2 enlarged dermal adipocytes independently of HF cycles by inhibiting sterol regulatory element\u2010binding protein\u20101, a transcription factor involved in cholesterol and fatty acid synthesis, which leads to the activation of cholesterol synthesis followed by expansion of the plasma and lipid droplet membrane. Immunohistochemical staining of paired mirror sections revealed a statistically significant increase in the ratio of IL\u201023\u2010producing macrophages in the dermal adipose tissue of rSLURP2\u2010injected skin compared with the control. Furthermore, IL\u201023p19 gene expression was significantly upregulated in rSLURP2\u2010treated skin. Taken together with the previous findings, the present study showed that SLURP2 has inflammatory and metabolic effects. Dermal adipose tissues may serve as a source of IL\u201023 in psoriatic lesions.\n                  <\/jats:p>","DOI":"10.1111\/exd.70304","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T08:43:08Z","timestamp":1783327388000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>SLURP2<\/scp>\n                    Enlarges Adipocytes and Induces\n                    <scp>IL<\/scp>\n                    \u201023\u2010Producing Macrophages in Murine Dermal Adipose Tissue"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6451-1315","authenticated-orcid":false,"given":"Hitomi","family":"Tsuji","sequence":"first","affiliation":[{"name":"Department of Dermatology Tokai University School of Medicine  Isehara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0945-1137","authenticated-orcid":false,"given":"Tomotaka","family":"Mabuchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokai University School of Medicine  Isehara Kanagawa 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