{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:50:41Z","timestamp":1787323841263,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3601800 to Q.L."],"award-info":[{"award-number":["2022YFC3601800 to Q.L."]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404155"],"award-info":[{"award-number":["82404155"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Despite the recognized association between bullous pemphigoid (BP) and psoriasis, the clinical and immunological profiles, and inflammation patterns of coexistence remain undefined. We therefore conducted a retrospective cohort study of 140 BP patients without psoriasis (BP alone group) and 24 BP patients with comorbid psoriasis (BP\u2010PsO group) to characterise these features. Average age of BP onset was significantly lower in the BP\u2010PsO group, compared with the BP alone group (median [IQR]: 67.00 [58.00\u201375.75] years vs. 75.00 [64.00\u201382.00] years) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.021). In the BP\u2010PsO group, 21 patients (87.5%) had coexisting active psoriatic plaques and BP lesions. The overall disease activity of BP was comparable between the BP\u2010PsO and BP alone groups, both showing typical BP immunological features. Serum IL\u201017A level was significantly elevated in the BP\u2010PsO group (median [IQR]: 18.29 [10.39\u201343.50] pg\/mL), compared with the BP alone group (median [IQR]: 10.36 [9.16\u201312.11] pg\/mL) and psoriasis alone groups (median [IQR]: 11.65 [10.10\u201312.78] pg\/mL), and correlated with disease activity. Flow cytometry confirmed enhanced IL\u201017A response in peripheral blood mononuclear cells from the BP\u2010PsO group, with an elevated proportion of CD4\n                    <jats:sup>+<\/jats:sup>\n                    IL\u201017A\n                    <jats:sup>+<\/jats:sup>\n                    cells and IL\u201017A\n                    <jats:sup>+<\/jats:sup>\n                    T follicular helper cells versus corresponding controls. IL\u201013 was comparably elevated in both the BP\u2010PsO and BP alone groups, relative to psoriasis alone group and healthy controls. In a representative case, inhibition of IL\u201017A led to concurrent remission of both diseases. BP with psoriasis shares foundational features with idiopathic BP, but represents a distinct clinical entity characterised by a predominant IL\u201017A signature, highlighting its potential as a therapeutic target.\n                  <\/jats:p>","DOI":"10.1111\/exd.70306","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T08:11:19Z","timestamp":1782720679000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Immunological Characteristics of Bullous Pemphigoid Patients With Psoriasis Comorbidity: A Retrospective Study"],"prefix":"10.1111","volume":"35","author":[{"given":"Li","family":"Lei","sequence":"first","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9414-2891","authenticated-orcid":false,"given":"Guirong","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Friendship Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhen","family":"He","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5374-6955","authenticated-orcid":false,"given":"Ke","family":"Jing","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suo","family":"Li","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiliang","family":"Li","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0144-3255","authenticated-orcid":false,"given":"Takashi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Graduate School of Medicine Osaka Metropolitan University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suying","family":"Feng","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-025-00925-z"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.02.013"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2300080"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16679"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50283-3"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.07.060"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.01.089"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2023.2428"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100123"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.65"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2102383"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314258"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.09.003"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.263"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12899"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17013"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20313"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.11.076"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.03.002"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00374209"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550510035677"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.03.016"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-018-8702-3"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.08.012"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00184-7"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00701"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18001"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adi2848"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag-1904-48"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1191782"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2024.3425"}],"container-title":["Experimental 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