{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:50:35Z","timestamp":1787323835452,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Acne vulgaris pathogenesis involves complex interactions between sebum hypersecretion, follicular hyperkeratinisation, microbial colonisation and inflammatory cascades. While the bacterial microbiome has been extensively studied, the role of the skin mycobiome, particularly lipophilic Malassezia species, remains less clearly defined in acne\u2010prone sites. To evaluate evidence for skin mycobiome involvement in acne pathogenesis, a structured narrative review was conducted in PubMed\/MEDLINE and PMC, synthesising findings from 14 cross\u2010sectional studies involving 1650 participants from diverse geographic and ancestry backgrounds. Across sequencing and culture\u2010based studies,\n                    <jats:italic>Malassezia<\/jats:italic>\n                    was the dominant fungal genus on healthy as well as acne\u2010prone skin; species\u2010level data most often identified\n                    <jats:italic>M. restricta<\/jats:italic>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>M. globosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    , with occasional reports of\n                    <jats:italic>M. furfur<\/jats:italic>\n                    . Although significant variations were observed in fungal abundance, discrepancies exist between studies due to differences in study design, sampling methods (surface swabs vs. comedone or pustule contents vs. pore strips), culture media (lipid\u2010supplemented vs. standard), molecular target (ITS1 rDNA vs. other loci) and population demographics. Multiple sequencing studies did not detect significant fungal alpha\/beta\u2010diversity differences between acne and non\u2010acne skin while confirming\n                    <jats:italic>Malassezia<\/jats:italic>\n                    species dominance. One study highlighted the potential underdiagnosis of\n                    <jats:italic>Malassezia<\/jats:italic>\n                    folliculitis in acne patients, suggesting that misdiagnosis may occur due to overlapping clinical presentations. Future studies should predefine primary outcomes, adjust for multiplicity, report sampling depth (surface vs. follicular), specify fungal rDNA region sequenced, use specific lipid\u2010supplemented media for\n                    <jats:italic>Malassezia<\/jats:italic>\n                    isolation when culturing, co\u2010profile bacteria and fungi, and add systematic clinical assessment of\n                    <jats:italic>Malassezia<\/jats:italic>\n                    folliculitis.\n                  <\/jats:p>","DOI":"10.1111\/exd.70308","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T07:13:46Z","timestamp":1783754026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Possible Role of Mycobiome in the Pathophysiology of Acne: Structured Narrative Review and Perspectives"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2816-4261","authenticated-orcid":false,"given":"Delphine","family":"Kerob","sequence":"first","affiliation":[{"name":"La Roche\u2010Posay Laboratoire Dermatologique  Levallois\u2010Perret France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-3183","authenticated-orcid":false,"given":"Samir","family":"Salah","sequence":"additional","affiliation":[{"name":"La Roche\u2010Posay Laboratoire Dermatologique  Levallois\u2010Perret France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3890-5923","authenticated-orcid":false,"given":"Susi Elaine","family":"Dal Belo","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Aulnay\u2010sous\u2010Bois France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9950-3734","authenticated-orcid":false,"given":"James","family":"Odeimi","sequence":"additional","affiliation":[{"name":"La Roche\u2010Posay Laboratoire Dermatologique  Levallois\u2010Perret France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2376-3249","authenticated-orcid":false,"given":"Cecile","family":"Clavaud","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Aulnay\u2010sous\u2010Bois France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3854-8851","authenticated-orcid":false,"given":"Ann'Laure","family":"Demessant\u2010Flavigny","sequence":"additional","affiliation":[{"name":"La Roche\u2010Posay Laboratoire Dermatologique  Levallois\u2010Perret France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,11]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.5538"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.06.045"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12061"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.47"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.10.062"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60321-8"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S315846"},{"key":"e_1_2_14_9_1","first-page":"1057","article-title":"Microbiome: Role in Inflammatory Skin Diseases","volume":"15","author":"Zhang X. 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