{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:50:48Z","timestamp":1787323848845,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102024\u201000345362"],"award-info":[{"award-number":["RS\u20102024\u201000345362"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Icariin, the principal active compound of\n                    <jats:italic>Epimedium<\/jats:italic>\n                    species used in traditional East Asian medicine, exhibits anti\u2010inflammatory and lipid\u2010regulating effects. However, its effects on human sebocytes and dermal fibroblasts, which could be implicated in the management of acne and atrophic scarring, remain unexplored. This study aimed to evaluate the effects of icariin on human sebocytes, keratinocytes and dermal fibroblasts. Icariin's effects on cell viability, lipid synthesis, inflammation, abnormal keratinization and extracellular matrix (ECM) synthesis were assessed using human SEB\u20101 sebocytes, HaCaT keratinocytes and Detroit 551 fibroblasts. Icariin modestly promoted the proliferation of SEB\u20101 sebocytes, HaCaT keratinocytes and Detroit 551 fibroblasts. It reduced mRNA levels of lipogenic and proinflammatory markers in SEB\u20101 sebocytes and HaCaT keratinocytes. Icariin counteracted arachidonic acid\u2010induced lipogenesis in SEB\u20101 sebocytes in parallel with modulation of the insulin\u2010like growth factor 1 receptor\/Akt signalling pathway. In Detroit 551 fibroblasts, it enhanced ECM protein expression and reduced the expression of ECM\u2010degrading enzymes, accompanied by upregulation of platelet\u2010derived growth factor receptor and latent transforming growth factor \u03b2 binding protein 4. In conclusion,\n                    <jats:bold>t<\/jats:bold>\n                    his study demonstrates that icariin modulates key pathophysiological processes of acne and promotes ECM synthesis, suggesting its potential as a novel therapeutic agent for managing both acne and atrophic acne scars.\n                  <\/jats:p>","DOI":"10.1111\/exd.70310","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T08:09:30Z","timestamp":1782720570000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Icariin Regulates Acne Pathophysiology and Extracellular Matrix Protein Synthesis: Implications for Acne Vulgaris and Atrophic Acne Scar Management"],"prefix":"10.1111","volume":"35","author":[{"given":"Dong Hyo","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine  Seoul Republic of Korea"},{"name":"Acne, Rosacea, 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