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However, the specific role of individual gut microbes remains poorly understood. In this study, the impact of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Prevotella copri<\/jats:italic>\n                    <\/jats:styled-content>\n                    (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. copri<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) on psoriasis development was examined and the underlying mechanisms were investigated. In an imiquimod (IMQ)\u2010induced mouse model, oral administration of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. copri<\/jats:italic>\n                    <\/jats:styled-content>\n                    exacerbated skin inflammation, increased epidermal thickness, promoted neutrophil infiltration and aggravated disease severity. In\u00a0vitro, stimulation with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. copri<\/jats:italic>\n                    <\/jats:styled-content>\n                    enhanced keratinocyte proliferation and pro\u2010inflammatory responses, thereby activating co\u2010cultured neutrophils. These effects were associated with activation of the NF\u2010\u03baB signalling pathway, as evidenced by increased phosphorylation of p65 and upregulation of inflammasome components. The inhibition of NF\u2010\u03baB signalling attenuated\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. copri<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2010induced keratinocyte hyperproliferation, neutrophil activation and inflammatory cytokine production. Our findings suggest that\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. copri<\/jats:italic>\n                    <\/jats:styled-content>\n                    promotes psoriasis progression via NF\u2010\u03baB\u2010mediated keratinocyte\u2013neutrophil crosstalk, potentially through a gut\u2010derived systemic inflammatory mechanism. Targeting the gut\u2013skin axis and NF\u2010\u03baB pathway may offer new therapeutic opportunities for psoriasis.\n                  <\/jats:p>","DOI":"10.1111\/exd.70317","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T08:09:31Z","timestamp":1784880571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>Prevotella copri<\/i>\n                    Exacerbates Psoriasis Through Keratinocyte\u2010Neutrophil Crosstalk via\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    Activation"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0643-112X","authenticated-orcid":false,"given":"Meijunzi","family":"Luo","sequence":"first","affiliation":[{"name":"Hunan University of Chinese Medicine  Changsha Hunan China"},{"name":"Department of Dermatology The Second Affiliated 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