{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:12:30Z","timestamp":1789567950896,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["CUP B63C22000680007"],"award-info":[{"award-number":["CUP B63C22000680007"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sweet syndrome (SS) is an autoinflammatory neutrophilic dermatosis characterized by abrupt\u2010onset inflammatory skin lesions and systemic symptoms, yet its molecular pathogenesis remains incompletely defined. To delineate disease\u2010specific inflammatory programmes, we performed NanoString\u2010based transcriptomic analysis of SS skin lesions and compared them with healthy control skin and pyoderma gangrenosum, a related neutrophilic dermatosis. SS exhibited a distinct inflammatory transcriptional signature marked by robust upregulation of type I and II interferon\u2013stimulated genes, including\n                    <jats:italic>CXCL9, CXCL10, GBP1, GBP5, IFIT2<\/jats:italic>\n                    and\n                    <jats:italic>IRF7<\/jats:italic>\n                    , distinguishing SS from both control groups. Cell type deconvolution analysis revealed enrichment of dendritic cells, consistent with a prominent type I interferon\u2010driven immune response. In parallel, SS lesions demonstrated altered immunoproteasome gene expression, with upregulation of immunoproteasome subunits\n                    <jats:italic>PSMB8, PSMB9<\/jats:italic>\n                    and\n                    <jats:italic>PSMB10<\/jats:italic>\n                    and downregulation of the constitutive subunit\n                    <jats:italic>PSMB7<\/jats:italic>\n                    suggesting functional remodelling of proteasomal activity. Together, these findings support a model in which dendritic cell\u2010driven interferon signalling promotes immunoproteasome remodelling and sustains neutrophilic inflammation in Sweet. This study identifies a prominent interferon signalling as a defining molecular feature of SS and highlights potential therapeutic opportunities within the interferon\u2013JAK\/STAT and proteasome pathways.\n                  <\/jats:p>","DOI":"10.1111\/exd.70323","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:09:13Z","timestamp":1783400953000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Type I and\n                    <scp>II<\/scp>\n                    Interferon Signalling Characterizes the Transcriptional Landscape of Sweet Syndrome"],"prefix":"10.1111","volume":"35","author":[{"given":"Laura","family":"Calabrese","sequence":"first","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurosciences Siena University Hospital  Siena Italy"},{"name":"Institute of Dermatology Catholic University of the Sacred Heart  Rome Italy"},{"name":"Department of Dermatology and Allergy University Hospital LMU  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0060-5870","authenticated-orcid":false,"given":"Chiara","family":"Moltrasio","sequence":"additional","affiliation":[{"name":"Dermatology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Romagnuolo","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurosciences Siena University Hospital  Siena Italy"},{"name":"Dermatology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia\u2010Charlotte","family":"Stadler","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital LMU  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8508-6189","authenticated-orcid":false,"given":"Zeno","family":"Fiocco","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital LMU  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Neulinger\u2010Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital LMU  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital LMU  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8315-3413","authenticated-orcid":false,"given":"Martina","family":"D'Onghia","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurosciences Siena University Hospital  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Rubegni","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurosciences Siena University Hospital  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Kerl","sequence":"additional","affiliation":[{"name":"Department of Dermatology Universit\u00e4tsspital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi K.","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital LMU  Munich Germany"},{"name":"Dr Phillip Frost Department of Dermatology and Cutaneous Surgery Miller School of Medicine, University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2258-8357","authenticated-orcid":false,"given":"Angelo V.","family":"Marzano","sequence":"additional","affiliation":[{"name":"Dermatology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Pathophysiology and Transplantation Universit\u00e0 Degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars E.","family":"French","sequence":"additional","affiliation":[{"name":"Dr Phillip Frost Department of Dermatology and Cutaneous Surgery Miller School of Medicine, University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1964.tb14541.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-022-00673-4"},{"key":"e_1_2_12_4_1","first-page":"645","article-title":"Sweet Syndrome: An Update on Clinical Aspects, Pathophysiology, and Treatment","volume":"159","author":"Calabrese L.","year":"2024","journal-title":"Italian Journal of Dermatology and 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