{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:50:33Z","timestamp":1787323833585,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030096"],"award-info":[{"award-number":["82030096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373471"],"award-info":[{"award-number":["82373471"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Psoriasis is a complex chronic inflammatory and autoimmune disease; therefore, reliable and human\u2010relevant animal models are essential for preclinical drug testing and mechanistic studies. SKH\u20101 mice, which lack functional hair follicles and display a thickened epidermis that more closely resembles human skin than that of C57BL\/6 mice, represent a potential psoriasis model, but their suitability remains uncertain. In this study, proliferation, barrier function, differentiation, and inflammatory responses were assessed in the imiquimod (IMQ)\u2010induced dermatitis model of SKH\u20101 mice using qRT\u2010PCR, immunofluorescence, and flow cytometry. Transcriptomic profiling via RNA sequencing was performed on total RNA from lesional and non\u2010lesional skin of IMQ\u2010induced SKH\u20101 mice, IMQ\u2010induced C57BL\/6 mice, and human psoriatic skin. A psoriasis\u2010like mouse model was also established in SKH\u20101 mice to evaluate its utility for recurrence studies. The results showed that the IMQ\u2010induced SKH\u20101 mouse model exhibited hyperproliferation, hypodifferentiation, barrier disruption, and excessive inflammatory responses similar to human psoriasis. Transcriptomic analysis further highlighted the advantages and complementarity of this model in studying psoriasis pathogenesis, and the established recurrence model provided a suitable tool for investigating the mechanisms of psoriasis recurrence. This study compared the transcriptomic signatures of lesional skin between IMQ\u2010induced SKH\u20101 and C57BL\/6 mice and demonstrated that the SKH\u20101 model can recapitulate vascular dysregulation and disease recurrence, indicating that it serves as a valuable complementary tool for probing psoriasis pathogenesis.<\/jats:p>","DOI":"10.1111\/exd.70324","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T06:22:08Z","timestamp":1783318928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Transcriptomics Reveals\n                    <scp>SKH<\/scp>\n                    \u20101 Mice as a Valuable Model for Psoriasis Pathogenesis and Recurrence Studies"],"prefix":"10.1111","volume":"35","author":[{"given":"Lixin","family":"Yue","sequence":"first","affiliation":[{"name":"Department of Dermatology Xijing Hospital, Fourth Military Medical University  Xi'an 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