{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:50:39Z","timestamp":1787323839940,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Acral vitiligo responds less well to NB\u2010UVB than non\u2010acral disease, but site\u2010specific immunologic changes during therapy are incompletely defined. The objective of this study was to compare NB\u2010UVB\u2013associated changes in T cell subsets and soluble mediators in acral versus non\u2010acral vitiligo. Thirty patients with non\u2010segmental vitiligo were enrolled. Ten underwent paired biopsies (acral and non\u2010acral) before and after 6\u2009months of NB\u2010UVB for flow cytometry (Tregs, CD8+ T cells, CD8+CD45RO+ memory T cells, CD8+CD69+CD103+ TRM). Suction\u2010blister fluid ELISA assessed IFN\u2010\u03b3\u2013axis mediators (CXCR3, CXCL9, CXCL10, IFN\u2010\n                    <jats:italic>\u03b3<\/jats:italic>\n                    , IL\u20101\u03b2) in two separate groups: 10 treatment\u2010na\u00efve patients and 10 patients who had completed 6\u2009months of NB\u2010UVB therapy. Non\u2010parametric tests used Benjamini\u2013Hochberg FDR correction (pFDR). In paired biopsies (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910; CD8\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20099), memory T cells decreased after NB\u2010UVB in acral (4.38 [3.47\u20135.98] to 1.38 [0.73\u20132.21]; pFDR\u2009=\u20090.041) and non\u2010acral lesions (5.23 [4.27\u20136.75] to 1.08 [0.48\u20132.54]; pFDR\u2009=\u20090.0039). TRM declined in acral (5.95 [3.17\u20137.41] to 0.65 [0.15\u20131.15]; pFDR\u2009=\u20090.0039) and non\u2010acral sites (4.12 [2.50\u20135.57] to 0.69 [0.28\u20131.19]; pFDR\u2009=\u20090.0039). Tregs showed a site\u2010divergent pattern: acral Tregs decreased (0.56 [0.41\u20130.75] to 0.08 [0.03\u20130.23]; pFDR\u2009=\u20090.0067) while non\u2010acral Tregs increased (0.40 [0.24\u20130.61] to 0.95 [0.41\u20131.59]; pFDR\u2009=\u20090.0039). CD8+ T cells showed no change after correction. CXCL9 showed a non\u2010significant decreasing trend (pFDR\u2009=\u20090.249); no ELISA marker remained significant after FDR correction. NB\u2010UVB exerts a pronounced effect on cellular immunity (reductions in TRM and memory T cells) with limited cytokine suppression, with site\u2010divergent Treg pattern.\n                  <\/jats:p>","DOI":"10.1111\/exd.70325","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T06:15:47Z","timestamp":1783491347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Site\u2010Specific Immunological Changes Induced by Narrowband\n                    <scp>UVB<\/scp>\n                    in Acral and Non\u2010Acral Vitiligo"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6323-4988","authenticated-orcid":false,"given":"Keshavamurthy","family":"Vinay","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7481-2330","authenticated-orcid":false,"given":"Hitaishi","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anish","family":"Thind","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitaishi","family":"Kaushik","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthu Sendhil","family":"Kumaran","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0348-0815","authenticated-orcid":false,"given":"Davinder","family":"Parsad","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(24)00026-4"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00631-6"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.32"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102868"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202250281"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.02.016"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.126"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.ijd_11_22"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S501688"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.10.032"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2960"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010302"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12960"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.09.016"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.04.027"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adu9360"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04215.x"}],"container-title":["Experimental 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