{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T06:06:41Z","timestamp":1788934001226,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011176","name":"Peking Union Medical College","doi-asserted-by":"publisher","award":["201920102303"],"award-info":[{"award-number":["201920102303"]}],"id":[{"id":"10.13039\/501100011176","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Dysbiosis of the skin microbiome, characterised by\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    overgrowth and imbalance of commensals such as\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n                    <\/jats:styled-content>\n                    (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. epidermidis<\/jats:italic>\n                    <\/jats:styled-content>\n                    ), is closely associated with atopic dermatitis (AD). However, the therapeutic relevance of defined\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. epidermidis<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2010associated indole metabolite, especially indole\u20103\u2010acetic acid (IAA), in AD\u2010like inflammation remains incompletely characterised. Here, we investigated the role of IAA, a tryptophan\u2010derived metabolite enriched in the culture supernatant of the tested\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. epidermidis<\/jats:italic>\n                    <\/jats:styled-content>\n                    strain, in AD\u2010like inflammation. Public transcriptomic analyses suggested impaired AHR\u2010associated and tryptophan\u2010metabolism signatures in AD skin, particularly in lesional skin, while human metagenomic data indicated AD\u2010associated staphylococcal alterations. Targeted metabolomics identified IAA as an enriched indole metabolite in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. epidermidis<\/jats:italic>\n                    <\/jats:styled-content>\n                    culture supernatant. In an MC903\u2010induced AD\u2010like mouse model, cutaneous IAA levels and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. epidermidis<\/jats:italic>\n                    <\/jats:styled-content>\n                    abundance were reduced. Topical IAA attenuated AD\u2010like phenotypes, improved barrier\u2010related proteins and reduced inflammatory indices. These protective effects were diminished by the AHR antagonist CH223191. Molecular docking predicted a possible interaction between IAA and AHR, and in\u00a0vitro assays showed that IAA modulated keratinocyte AHR\u2010associated inflammatory and barrier\u2010related responses. Together, our findings support IAA as a microbiome\u2010associated postbiotic candidate for AD management, at least partly through AHR\u2010associated signalling.\n                  <\/jats:p>","DOI":"10.1111\/exd.70329","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T06:00:33Z","timestamp":1787032833000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Topical Application of Indole\u20103\u2010Acetic Acid, Present in\n                    <scp>\n                      <i>S. epidermidis<\/i>\n                    <\/scp>\n                    Supernatant, Alleviates Atopic Dermatitis in Mice at Least via the Aryl Hydrocarbon Receptor Signalling Pathway"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0032-9007","authenticated-orcid":false,"given":"Piao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology China\u2010Japan Friendship Hospital, Capital Medical University  Beijing China"},{"name":"Department of Dermatology China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology China\u2010Japan Friendship Hospital, Capital Medical University  Beijing China"},{"name":"Department of Dermatology China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology China\u2010Japan Friendship Hospital  Beijing China"},{"name":"Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3723-5669","authenticated-orcid":false,"given":"Lingbo","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Dermatology China\u2010Japan Friendship Hospital  Beijing China"},{"name":"Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0531-3382","authenticated-orcid":false,"given":"Zining","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Dermatology China\u2010Japan Friendship Hospital, Capital Medical University  Beijing China"},{"name":"Department of Dermatology China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6022-3359","authenticated-orcid":false,"given":"Yujun","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6314-3610","authenticated-orcid":false,"given":"Yong","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Dermatology China\u2010Japan Friendship Hospital, Capital Medical University  Beijing China"},{"name":"Department of Dermatology China\u2010Japan Friendship Hospital  Beijing China"},{"name":"Chinese Academy of Medical Sciences &amp; Peking 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