{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:50:43Z","timestamp":1787323843931,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2025JH2\/101800028"],"award-info":[{"award-number":["2025JH2\/101800028"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2023\u2010MSLH\u2010363"],"award-info":[{"award-number":["2023\u2010MSLH\u2010363"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8240122147"],"award-info":[{"award-number":["8240122147"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Translating hidradenitis suppurativa (HS) genetic susceptibility into actionable targets remains challenging, as most genome\u2010wide association study loci lie in non\u2010coding regions and tissue\u2010level transcriptomics cannot easily distinguish causal drivers from secondary inflammation. In this study, we aimed to prioritize plasma proteins whose genetically predicted levels are causally associated with HS risk and to localize them within human skin at single\u2010cell resolution. We performed two\u2010sample Mendelian randomization (MR) using\n                    <jats:italic>cis<\/jats:italic>\n                    \u2010pQTL instruments for 2923 plasma proteins from the UK Biobank Pharma Proteomics Project against HS summary statistics from FinnGen R12. Following multiple\u2010testing correction and Bayesian colocalization with a prior\u2010sensitivity grid, the intersection of false\u2010discovery rate (FDR)\u2010significant MR with colocalization evidence (PP.H\n                    <jats:sub>4<\/jats:sub>\n                    \u2009\u2265\u20090.5) yielded three putative protective candidates: TNFRSF6B (OR\u2009=\u20090.748, 95% CI 0.666\u20130.840; PP.H\n                    <jats:sub>4<\/jats:sub>\n                    \u2009=\u20090.648), FCRL2 (OR\u2009=\u20090.896, 95% CI 0.819\u20130.979; PP.H\n                    <jats:sub>4<\/jats:sub>\n                    \u2009=\u20090.550), and APOD (OR\u2009=\u20090.789, 95% CI 0.647\u20130.963; PP.H\n                    <jats:sub>4<\/jats:sub>\n                    \u2009=\u20090.503). All sensitivity MR tests were concordant. Single\u2010cell transcriptomic analysis localized FCRL2 and APOD to specific cell populations. FCRL2 was predominantly expressed in B cells and NK cells, while APOD showed multi\u2010cellular expression across cornified keratinocytes, macrophages, and dendritic cells. Furthermore, TNFRSF6B was below the skin detection threshold, supporting its biological role as a circulating decoy receptor. Together, our integrated proteogenomic and single\u2010cell approach prioritizes TNFRSF6B, FCRL2, and APOD as putative protective plasma proteins for HS, with TNFRSF6B emerging as the most genetically robust candidate for future translational follow\u2010up.\n                  <\/jats:p>","DOI":"10.1111\/exd.70332","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:43:12Z","timestamp":1784958192000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Proteogenomics and Single\u2010Cell Transcriptomics Prioritize Putative Protective Plasma Proteins for Hidradenitis Suppurativa"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3209-7184","authenticated-orcid":false,"given":"Yuzhe","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Dermatology General Hospital of Northern Theatre Command  Shenyang China"},{"name":"Graduate School, China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2978-1413","authenticated-orcid":false,"given":"Jingyi","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Dermatology General Hospital of Northern Theatre Command  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7371-917X","authenticated-orcid":false,"given":"Jun","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Dermatology General Hospital of Northern Theatre Command  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2025.2373"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae238"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16147"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.12.651"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.4926"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljaf277"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010025\u201002291\u20102"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010023\u201001588\u2010w"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201006592\u20106"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005473\u20108"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.05.012"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq151"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004383"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010023\u201001767\u2010y"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.01.011"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20220236"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.11.010"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12311"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2024.12.004"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.01.148"}],"container-title":["Experimental 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