{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:19:39Z","timestamp":1789586379992,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Nevus\u2010associated melanoma (NAM) is histologically defined by coexisting nevus and melanoma components, yet the nevus component is frequently not visible on dermoscopy.<\/jats:p>\n                    <jats:p>We performed a retrospective, single\u2010centre observational study including histologically diagnosed NAMs (2011\u20132024). Dermoscopic images were assessed independently by two readers. Histopathology was systematically revised to quantify nevus proportion, size, and depth. Univariate and multivariable logistic regression evaluated associations with (a) invasive vs. in\u00a0situ NAM and (b) dermoscopically visible vs. non\u2010visible nevus component.<\/jats:p>\n                    <jats:p>Among 340 NAMs, 36.8% were in\u00a0situ and 63.2% invasive. A dermoscopic nevus was visible in 45.6%. In multivariable analysis, nevus visibility under dermoscopy was independently associated with histopathologic features such as larger nevus size, particularly 2.1\u20134\u2009mm (OR 2.5, 95% CI 1.3\u20134.6), 4.1\u201310\u2009mm (OR 3.7, 95% CI 2.0\u20137.0), and\u2009&gt;\u200910\u2009mm (OR 5.3, 95% CI 1.4\u201320.0), whereas deep nevus location (OR 0.3, 95% CI 0.2\u20130.5) and ulceration (OR 0.2, 95% CI 0.1\u20130.6) reduced visibility. Invasive NAM was independently associated with a visible nevus component under dermoscopy (OR 2.5, 95% CI 1.7\u20133.7), shiny white structures (OR 5.0, 95% CI 2.6\u20139.4), negative pigment network (OR 1.9, 95% CI 1.2\u20133.2), and blue\u2010white veil (OR 8.3, 95% CI 4.5\u201315.4), whereas atypical pigment network and melanoma pigmentation were inversely associated with invasion.<\/jats:p>\n                    <jats:p>Dermoscopic nevus visibility in NAM is mainly determined by nevus size and depth, while melanoma\u2010related changes, particularly ulceration, can obscure the nevus component. Dermoscopic markers of invasiveness should prompt timely management even when an associated nevus is suspected.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/exd.70333","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:55:17Z","timestamp":1785394517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dermoscopic\u2010Pathologic Correlates of Invasiveness and Nevus Visibility in Nevus\u2010Associated Melanoma"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3509-4222","authenticated-orcid":false,"given":"Marco","family":"Spadafora","sequence":"first","affiliation":[{"name":"Department of Surgery, Medicine, Dental Medicine and Morphological Sciences University of Modena and Reggio Emilia  Modena Italy"},{"name":"Azienda Unit\u00e0 Sanitaria Locale \u2013 IRCCS di Reggio Emilia Skin Cancer Center  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9245-8939","authenticated-orcid":false,"given":"Erica","family":"Baschieri","sequence":"additional","affiliation":[{"name":"Department of Dermatology Azienda Ospedaliero\u2010Universitaria Policlinico di Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4875-6977","authenticated-orcid":false,"given":"Simonetta","family":"Piana","sequence":"additional","affiliation":[{"name":"Pathology Unit Azienda Unit\u00e0 Sanitaria Locale \u2010 IRCCS di Reggio Emilia  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1166-2961","authenticated-orcid":false,"given":"Shaniko","family":"Kaleci","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medicine, Dental Medicine and Morphological Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Santandrea","sequence":"additional","affiliation":[{"name":"Pathology Unit Azienda Unit\u00e0 Sanitaria Locale \u2010 IRCCS di Reggio Emilia  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pellacani","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medicine, Dental Medicine and Morphological Sciences University of Modena and Reggio Emilia  Modena Italy"},{"name":"Department of Dermatology Azienda Ospedaliero\u2010Universitaria Policlinico di Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0392-0488.19.06534-9"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18453"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17133"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.06.149"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.12.036"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008980919928"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14918"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2009"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.04.120"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16604"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3780"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1588"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.311"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10194.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.0802a07"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-020-00858-4"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llaf354"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.01.025"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja17.00232"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19819"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.70154"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.01.012"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.1348"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15784"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.28"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.05.080"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2023.4454"}],"container-title":["Experimental 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