{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:50:50Z","timestamp":1787323850310,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Head and neck dermatitis (HND) is a distinct clinical phenotype of atopic dermatitis (AD). While\n Malassezia<\/jats:italic>\n sensitisation and elevated\n Malassezia<\/jats:italic>\n \u2010specific IgE antibody (MSIA) levels have been documented in HND patients, the relationship between MSIA levels and disease severity remains controversial. The primary aim of our study was to evaluate whether MSIA levels correlate with the severity of HND. This retrospective observational study was conducted at a single tertiary center and included 121 patients with AD. Laboratory data included serum MSIA, house dust mite (HDM)\u2010specific IgE and total IgE levels. Clinical severity was measured using the global Eczema Area and Severity Index (EASI) and partial HND EASI scores. We introduced a novel metric, the \u2018relative HND severity score\u2019, defined as the HND EASI score divided by the global EASI score. Spearman's Rho correlation analyses were used to examine the correlations between different IgE levels and severity scores. The HND EASI score demonstrated significant positive correlations with MSIA (\n r<\/jats:italic>\n \u2009=\u20090.569,\n p<\/jats:italic>\n \u2009<\u20090.001) and both HDM\u2010specific antibodies:\n D1<\/jats:italic>\n (\n r<\/jats:italic>\n \u2009=\u20090.247,\n p<\/jats:italic>\n \u2009=\u20090.007) and\n D2<\/jats:italic>\n (\n r<\/jats:italic>\n \u2009=\u20090.267,\n p<\/jats:italic>\n \u2009=\u20090.004). The relative HND severity score was significantly positively correlated with MSIA (\n r<\/jats:italic>\n \u2009=\u20090.353,\n p<\/jats:italic>\n \u2009<\u20090.001), but not with HDM\u2010specific antibodies (\n D1<\/jats:italic>\n ,\n p<\/jats:italic>\n \u2009=\u20090.985;\n D2<\/jats:italic>\n ,\n p<\/jats:italic>\n \u2009=\u20090.974). Age\u2010stratified subgroup analyses revealed significant positive correlations between MSIA and both absolute (\n r<\/jats:italic>\n \u2009=\u20090.591,\n p<\/jats:italic>\n \u2009<\u20090.001) and relative HND severity (\n r<\/jats:italic>\n \u2009=\u20090.344,\n p<\/jats:italic>\n \u2009=\u20090.002) only in the adult cohort. In conclusion, serum MSIA levels significantly correlate with the clinical severity of HND in Korean AD patients. This association is most clearly observed in the adult population.\n <\/jats:p>","DOI":"10.1111\/exd.70334","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:41:56Z","timestamp":1784958116000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Significance of\n Malassezia<\/i>\n \u2010Specific\n IgE<\/scp>\n in Assessing the Severity of Head and Neck Involvement in Korean Atopic Dermatitis Patients"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2423-2343","authenticated-orcid":false,"given":"Han\u2010Na","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology Korea University College of Medicine, Guro Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6777-5099","authenticated-orcid":false,"given":"Jaewon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Korea University College of Medicine, Guro Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2953-8811","authenticated-orcid":false,"given":"Anna","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Korea University College of Medicine, Guro Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4141-204X","authenticated-orcid":false,"given":"Ko Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Korea University College of Medicine, Guro Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8667-2814","authenticated-orcid":false,"given":"Yoo Sang","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Dermatology Korea University College of Medicine, Guro Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2456-7573","authenticated-orcid":false,"given":"Jiehyun","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Dermatology Korea University College of Medicine, Guro Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02519-4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.07.012"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13642"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14437"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.2020.5422"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14368"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.04.052"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.07.058"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00112"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1114321"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-024-09000-7"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.4.545-563.2002"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2004.00097.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000086438"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/645670"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000040"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.15108"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01108.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm4061217"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00782.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08193.x"},{"issue":"2","key":"e_1_2_10_23_1","article-title":"Study of Hypersensitivity to Malassezia Furfur in Patients With Atopic Dermatitis With Head and Neck Pattern: Is It Useful as a Biomarker and Therapeutic Indicator in These Patients?","volume":"12","author":"Navarro\u2010Trivi\u00f1o F. 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