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Beyond their contributions to innate defence and the skin's microbiome, AMPs have been implicated in inflammatory skin conditions and cutaneous malignancies. Comprehensive summaries of AMPs' roles in skin cancer and related current clinical developments remain scarce, despite abundant emerging evidence of pro\u2010 and anti\u2010tumour properties in other fields. This review provides a comprehensive discussion of AMPs, including dermcidin, psoriasin (S100A7), human cathelicidin (LL\u201037), RNase\u20107 and the human \u03b2\u2010defensins, in the context of skin cancer research and clinical developments. These AMPs influence skin tumorigenesis through microbiome regulation, innate immune pathways and chronic inflammation, and although the mechanistic details are subject to scrutiny, several AMP\u2010derived therapies, including LL\u201037 and LTX\u2010315, have been developed for their potential in cutaneous oncology.<\/jats:p>","DOI":"10.1111\/exd.70341","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T05:42:08Z","timestamp":1786426928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antimicrobial Peptides of the Skin: Roles in Skin Cancer and Clinical Applications"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4461-1965","authenticated-orcid":false,"given":"Elizabeth","family":"Botto","sequence":"first","affiliation":[{"name":"Morsani College of Medicine University of South Florida  Tampa Florida 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