{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T06:06:41Z","timestamp":1788934001935,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["113\u2010E0002"],"award-info":[{"award-number":["113\u2010E0002"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["114\u2010E0006"],"award-info":[{"award-number":["114\u2010E0006"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112\u20102314\u2010B\u2010002\u2010159\u2010MY3"],"award-info":[{"award-number":["112\u20102314\u2010B\u2010002\u2010159\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["113\u20102314\u2010B\u2010002\u2010033"],"award-info":[{"award-number":["113\u20102314\u2010B\u2010002\u2010033"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["114\u20102314\u2010B\u2010002\u2010022"],"award-info":[{"award-number":["114\u20102314\u2010B\u2010002\u2010022"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Female\u2010pattern hair loss is common in obese women with polycystic ovary syndrome (PCOS), recently proposed as polyendocrine metabolic ovarian syndrome (PMOS) and is often associated with hypertriglyceridemia (TG), although the underlying mechanisms remain unclear. This study investigated how metabolic factors and androgens contribute to hair loss in female mice exposed to a high\u2010fat diet (HFD). A controlled, parallel\u2010group study using 8\u2010week\u2010old female C57BL\/6 mice fed either an HFD (60% kcal fat) or a standard diet for 16\u2009weeks. Mice were sacrificed at baseline and 4\u2010week intervals for serial evaluation of metabolic, hormonal and skin changes (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096\/group\/time point). Hair loss was quantified from digital photographs using the ImageJ and further supported by histological examination. Circulating metabolic and hormonal profiles were measured. In dorsal skin, oxidative stress (malondialdehyde, MDA) and androgen\u2010related markers\u20145\u2010alpha\u2010reductase type II (5\u03b1R2), dihydrotestosterone (DHT) and androgen receptor (AR)\u2014were evaluated using immunohistochemistry, Western blot and enzyme\u2010linked immunosorbent assay. From Week 12 onward, HFD\u2010fed mice exhibited greater weight gain, pronounced dorsal hair thinning and elevated TG, insulin and free androgen index (FAI) levels. Skin MDA, 5\u03b1R2, DHT and AR levels also progressively increased. In the second experiment, 8\u2010week\u2010old female mice were assigned to four groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096\/group): HFD with N\u2010acetylcysteine (NAC), finasteride, spironolactone, or vehicle administered by oral gavage for 12\u2009weeks. Compared with HFD\u2010vehicle, antioxidant or anti\u2010androgen co\u2010treatment significantly lowered serum TG, tissue MDA and ameliorated hair thinning despite similar weight gain and 5\u03b1R2 levels. NAC reduced TG, FAI and decreased tissue MDA, DHT and AR. Finasteride lowered TG, MDA, DHT and AR, whereas spironolactone reduced TG and MDA. HFD\u2010induced obesity exacerbates hair loss in female mice by enhancing oxidative stress and activating androgen signalling in the skin. Targeting these pathways, such as antioxidants and antiandrogens, may mitigate HFD\u2010accelerated hair loss.\n                  <\/jats:p>","DOI":"10.1111\/exd.70343","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T04:43:47Z","timestamp":1786509827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diet\u2010Induced Obesity Promotes Alopecia Through Oxidative Stress and Androgen Signalling in Female Mice"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5578-2706","authenticated-orcid":false,"given":"Yi\u2010An","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology National Taiwan University Hospital and College of Medicine, National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Hung","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology National Taiwan University Hospital and College of Medicine, National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koping","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pathology National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department and Graduate Institute of Forensic Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6127-2811","authenticated-orcid":false,"given":"Chu\u2010Chun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology National Taiwan University Hospital and College of Medicine, National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Nerng","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology National Taiwan University Hospital and College of Medicine, National Taiwan University  Taipei Taiwan"},{"name":"Research Center for Cell Therapy and Regeneration Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2305-1105","authenticated-orcid":false,"given":"Mei\u2010Jou","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology National Taiwan University Hospital and College of Medicine, National Taiwan University  Taipei Taiwan"},{"name":"Livia Shan\u2010Yu Wan Chair Professor of Obstetrics and Gynecology National Taiwan University  Taipei 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