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Umbilical cord (UC) and umbilical cord blood (UCB)\u2010based therapies have therefore emerged as an area of research interest that aims to address current limitations in wound management. This scoping review summarises the extent of research into these therapies, including mechanisms of action, clinical translation and artificial modifications. A systematic search of two electronic databases (PubMed and Embase\u2010Ovid) was carried out before supplementation with reference list screening and citation tracking. Of the 133 included articles, there were 20 in\u00a0vitro studies, 19 review articles, 1 editorial, 16 human studies and 77 animal studies. UC and UCB\u2010based therapies consist of cellular and acellular factors that act through paracrine mechanisms rather than direct differentiation. Immunomodulation, growth stimulation, angiogenesis and anti\u2010apoptosis are the main mechanisms by which these therapies exert their effect, and initial reports provide some evidence that these therapies could be useful clinically. Nevertheless, such preliminary evidence is limited by study heterogeneity, short follow\u2010up durations and small sample sizes. Various modifications to these therapies, such as preconditioning, are also being explored to increase treatment yield. Although infection and multi\u2010organ effects are common safety concerns, current literature has also yet to establish long\u2010term safety. Preclinical data on UC\u2010based therapies appear promising; however, larger multicentric human trials are essential to validate clinical efficacy. 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