{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:55:54Z","timestamp":1790841354301,"version":"4.1.0"},"reference-count":111,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473549"],"award-info":[{"award-number":["82473549"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This review examines age\u2010related hair greying as a potential imbalance in the HFSC\u2013MeSC\u2013niche network in terms of time, space and signal quality. We define signal quality as the effective strength, temporal precision and noise\u2010to\u2010threshold relationship of niche\u2010derived cues that regulate MeSC activation. We propose that ageing may progressively weaken the temporal coordination between HFSC activation and MeSC responsiveness. ECM remodelling and altered guidance\u2010related cues may further impair MeSC niche engagement. Meanwhile, chronic oxidative stress, low\u2010grade inflammation and stress\u2010related sympathetic norepinephrine signalling may increase background noise, distort signal timing and push the MeSC activation threshold upward, so residual MeSC\u2010lineage cells may fail to engage effectively with the niche. Such functional uncoupling may represent an early or intermediate stage, whereas sustained genotoxic stress or niche failure can eventually drive irreversible MeSC depletion. Based on this, the article constructs an integrative model, emphasizing that future intervention strategies may need to shift from simply protecting MeSCs to preserving the temporal and spatial coupling of the HFSC\u2013MeSC\u2013niche network. Potential approaches may include reducing chronic niche stress, maintaining HFSC\u2013MeSC communication, preserving ECM organization and improving the timing and strength of pro\u2010pigmentation cues. We further propose that hair greying may provide an accessible visual readout of stem\u2010cell niche ageing.<\/jats:p>","DOI":"10.1111\/exd.70365","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:01:40Z","timestamp":1790838100000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Spatiotemporal Coupling Imbalance of Senescent Grey Hair: Remodelling of the\n                    <scp>HFSC<\/scp>\n                    \u2013\n                    <scp>MeSC<\/scp>\n                    \u2013Niche Network and a New Paradigm of Stem Cell Senescence"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2885-7086","authenticated-orcid":false,"given":"Hanyu","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Dermatology Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0747-2516","authenticated-orcid":false,"given":"Xiuzu","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hangzhou Third People's Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"issue":"1","key":"e_1_2_13_2_1","first-page":"38","article-title":"Hair Aging in Different Races and Ethnicities","volume":"14","author":"Maymone M. 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