{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T07:37:09Z","timestamp":1792913829681,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Senescent cells affect neighbouring cells via the senescence\u2010associated secretory phenotype (SASP), which involves proinflammatory cytokines, chemokines and proteases.\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Camellia sinensis<\/jats:italic>\n                    <\/jats:styled-content>\n                    root extract (SENOMUNE) has shown therapeutic potential for skin aging\u2010related disorders. However, whether it exerts senolytic effect remains to be explored. Thus, this study aimed to assess the senolytic properties of SENOMUNE in a stress\u2010induced premature senescence model in normal human dermal fibroblasts (NHDFs) through cell viability assays, quantitative reverse transcription polymerase chain reaction, western blot and flow cytometry. NHDFs were induced to senescence using doxorubicin and insulin\u2010like growth factor\u20101. The senolytic effect of SENOMUNE was evaluated by measuring senescence\u2010associated \u03b2\u2010galactosidase activity, gene and protein expression, and the apoptosis rate. SENOMUNE reduced the viability of senescent cells in a dose\u2010dependent manner, with a more pronounced effect in senescent cells than in control cells. It was also associated with caspase\u2010independent programmed cell death involving apoptosis\u2010inducing factor and lysosomal membrane permeabilization in senescent cells. Moreover, SENOMUNE reduced the production of SASP factors, increased the expression of skin barrier\u2010associated markers, and attenuated pigmentation by modulating the secretion of inflammatory cytokines. These effects were evaluated using conditioned media derived from senescent fibroblasts and validated through ex\u00a0vivo skin biopsy experiments. Our results suggest that SENOMUNE exhibits senolytic properties and thus is a promising anti\u2010aging phytopharmaceutical ingredient for managing skin\u2010related disorders.\n                  <\/jats:p>","DOI":"10.1111\/exd.70366","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:02:15Z","timestamp":1791878535000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plant\u2010Derived Senolytic Ingredient,\n                    <scp>\n                      <i>Camellia sinensis<\/i>\n                    <\/scp>\n                    Root Extract, Ameliorates Skin Aging\u2010Associated Phenotypes"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2924-3121","authenticated-orcid":false,"given":"Sunyoung","family":"Park","sequence":"first","affiliation":[{"name":"Research and Innovation Center Amorepacific  Yongin Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0403-5599","authenticated-orcid":false,"given":"Siyoung","family":"Cho","sequence":"additional","affiliation":[{"name":"Research and Innovation Center Amorepacific  Yongin Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9895-0183","authenticated-orcid":false,"given":"Daejin","family":"Min","sequence":"additional","affiliation":[{"name":"Research and Innovation Center Amorepacific  Yongin Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4435-2801","authenticated-orcid":false,"given":"Hyunjung","family":"Choi","sequence":"additional","affiliation":[{"name":"Research and Innovation Center Amorepacific  Yongin Republic of 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0839-1264","authenticated-orcid":false,"given":"Hyoung\u2010June","family":"Kim","sequence":"additional","affiliation":[{"name":"Research and Innovation Center Amorepacific  Yongin Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64098"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2019.52.1.293"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2017.01.004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13141"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.343129.120"},{"key":"e_1_2_10_7_1","first-page":"46","article-title":"Understanding the Structure and Function of the 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