{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:58:45Z","timestamp":1790672325804,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Autophagy is increasingly recognised as a regulator of epithelial stress adaptation in the skin, but its role in inflammatory dermatoses remains difficult to interpret because autophagy intersects with barrier biology, keratinocyte differentiation, immune signalling, intracellular trafficking and lysosomal degradation. Keratinocytes are immune\u2010competent epithelial cells that integrate cytokine exposure, oxidative stress, microbial sensing and tissue injury into inflammatory output. In this review, we synthesize evidence on keratinocyte autophagy as a disease\u2010dependent regulator of epidermal homeostasis and cutaneous inflammation. We summarize core autophagy machinery, selective autophagy programs relevant to epidermal differentiation and the interpretive value of autophagic flux and lysosomal competence. We then discuss how autophagy influences keratinocyte differentiation, organelle clearance, lipid handling, barrier support, inflammatory restraint and stress adaptation. Disease\u2010specific evidence is reviewed in psoriasis, AP1S3\u2010associated pustular autoinflammation, atopic dermatitis and vitiligo. Across these settings, keratinocyte autophagy cannot be classified as uniformly protective or pathogenic; its effects depend on inflammatory context, trafficking state, cell\u2010type\u2010specific outputs and the ability of lysosomes to complete degradation. We also consider lessons from other barrier epithelia, therapeutic implications and common methodological limitations. A keratinocyte\u2010centered, flux\u2010aware interpretation provides a framework for organizing disease\u2010specific autophagy biology and for designing more rigorous mechanistic studies in inflammatory dermatoses.<\/jats:p>","DOI":"10.1111\/exd.70370","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:04:25Z","timestamp":1790669065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Keratinocyte Autophagy in Inflammatory Dermatoses: Mechanisms, Disease\u2010Specific Programs and Therapeutic Opportunities"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1701-6304","authenticated-orcid":false,"given":"Yulu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8621-6538","authenticated-orcid":false,"given":"Kevin M.","family":"Truong\u2010Balderas","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8815-8569","authenticated-orcid":false,"given":"Claudia","family":"Lasalle","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4830-5104","authenticated-orcid":false,"given":"Sabrina","family":"Schundler","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5594-0599","authenticated-orcid":false,"given":"Bethany E.","family":"Perez White","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2906-2454","authenticated-orcid":false,"given":"Kyle T.","family":"Amber","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0857-0556","authenticated-orcid":false,"given":"Adrian P.","family":"Mansini","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"issue":"20","key":"e_1_2_15_2_1","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.142067","article-title":"Cytokinocytes: The Diverse Contribution of Keratinocytes to Immune Responses in Skin","volume":"5","author":"Jiang Y.","year":"2020","journal-title":"JCI Insight"},{"issue":"11","key":"e_1_2_15_3_1","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1016\/j.jid.2024.06.1280","article-title":"The Central Roles of Keratinocytes in Coordinating Skin Immunity","volume":"144","author":"Simmons J.","year":"2024","journal-title":"Journal of Investigative Dermatology"},{"issue":"31","key":"e_1_2_15_4_1","doi-asserted-by":"crossref","first-page":"50682","DOI":"10.18632\/oncotarget.9330","article-title":"The Signaling Involved in Autophagy Machinery in Keratinocytes and Therapeutic Approaches for Skin Diseases","volume":"7","author":"Li L.","year":"2016","journal-title":"Oncotarget"},{"issue":"8","key":"e_1_2_15_5_1","article-title":"Autophagy: Guardian of Skin Barrier","volume":"10","author":"Kim H. 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