{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:49:26Z","timestamp":1791881366914,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Interleukin\u20106 (IL\u20106) and the neuropeptide calcitonin gene\u2010related peptide (CGRP) promote the generation of T helper 17 (Th17) cells. Th17\u2010type immunity is involved in several autoimmune disorders, including psoriasis. Also, there is evidence that sensory nerves play a role in Th17\u2010type immunity, including in psoriasis. Vitamin D (VD) blood levels vary inversely with the severity of psoriasis, and topical VD analogs are effective treatments for this disease. We have now asked whether 25\u2010dihydroxyvitamin D3 [25(OH)D\n                    <jats:sub>3<\/jats:sub>\n                    ] and the more potent, active analog 1\u03b1,25\u2010dihydroxyvitamin D3 [1\u03b1,25(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    ] inhibit IL\u20106 and\/or \u03b1\u2010CGRP production by transformed mouse embryonic dorsal root ganglion (DRG) neurons (MED17.11 cells), which serve as a surrogate for primary DRG neurons. After culture in differentiation medium, MED17.11 cells express markers of mature DRG neurons. Lymph nodes are innervated, so IL\u20106 and CGRP released from nerves are anatomically situated to influence Th17 cell generation. MED17.11 cells were cultured in differentiation medium for 48\u2010h to induce differentiation; then, medium in each well was replaced with fresh differentiation medium containing a range of concentrations of 25(OH)D\n                    <jats:sub>3<\/jats:sub>\n                    or 1\u03b1,25(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    . Twenty\u2010four and 48\u2010h later, supernatants were collected, and cells were harvested and lysed. IL\u20106 and \u03b1\u2010CGRP content of supernatants and lysates were assessed by ELISA. Both 25(OH)D\n                    <jats:sub>3<\/jats:sub>\n                    and 1\u03b1,25(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    significantly inhibited IL\u20106 content of supernatants and \u03b1\u2010CGRP content of cell lysates in a dose\u2010dependent manner with 1\u03b1,25(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    being more potent. 25(OH)D\n                    <jats:sub>3<\/jats:sub>\n                    and 1\u03b1,25(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    also inhibited expression of IL\u20106 mRNA. VD may beneficially affect disorders involving Th17\u2010type immunity by decreasing expression of IL\u20106 and \u03b1\u2010CGRP by DRG nerves.\n                  <\/jats:p>","DOI":"10.1111\/exd.70374","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:11:42Z","timestamp":1791879102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vitamin\n                    <scp>D3<\/scp>\n                    Inhibits Expression of Interleukin\u20106 and Calcitonin Gene\u2010Related Peptide by Transformed Dorsal Root Ganglion Neurons"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9554-0055","authenticated-orcid":false,"given":"Jiong","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Dermatology Weill Cornell Medical College  New York New York USA"},{"name":"Department of Dermatology, Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanhong","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Dermatology Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori L.","family":"Stohl","sequence":"additional","affiliation":[{"name":"Department of Dermatology Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8753-7619","authenticated-orcid":false,"given":"Katherine","family":"Alerte","sequence":"additional","affiliation":[{"name":"Department of Dermatology Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8942-439X","authenticated-orcid":false,"given":"Xi K.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2278-698X","authenticated-orcid":false,"given":"Sarah A.","family":"Commaroto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharan","family":"Grover","sequence":"additional","affiliation":[{"name":"Department of Dermatology Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almayasa","family":"Al\u2010Marri","sequence":"additional","affiliation":[{"name":"Department of Dermatology Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2824-7411","authenticated-orcid":false,"given":"Richard D.","family":"Granstein","sequence":"additional","affiliation":[{"name":"Department of Dermatology Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"issue":"15","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23158575","article-title":"Vitamin D Signaling in Psoriasis: Pathogenesis and Therapy","volume":"23","author":"Brozyna A. 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N.","year":"2021","journal-title":"Journal of Dermatological Science"},{"issue":"8","key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1016\/j.jid.2022.01.002","article-title":"Lidocaine Ameliorates Psoriasis by Obstructing Pathogenic CGRP Signaling\u2013Mediated Sensory Neuron\u2013Dendritic Cell Communication","volume":"142","author":"Yin Q.","year":"2022","journal-title":"Journal of Investigative Dermatology"},{"issue":"2","key":"e_1_2_10_26_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s40257-017-0323-8","article-title":"Vitamin D and the Skin: An Update for Dermatologists","volume":"19","author":"Kechichian E.","year":"2018","journal-title":"American Journal of Clinical Dermatology"},{"issue":"3","key":"e_1_2_10_27_1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2174\/187153012802002901","article-title":"Classical to Current Approach for Treatment of Psoriasis: A Review","volume":"12","author":"Rahman M.","year":"2012","journal-title":"Endocrine, Metabolic & Immune Disorders Drug Targets"},{"issue":"3","key":"e_1_2_10_28_1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1177\/10600280221105508","article-title":"Review of Calcipotriene and Betamethasone Dipropionate Cream in the Treatment of Psoriasis","volume":"57","author":"Taylor A.","year":"2023","journal-title":"Annals of Pharmacotherapy"},{"issue":"1","key":"e_1_2_10_29_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/sji.12304","article-title":"The Vitamin D Analogue Calcipotriol Reduces the Frequency of CD8+ IL\u201017+ T Cells in Psoriasis Lesions","volume":"82","author":"Dyring\u2010Andersen B.","year":"2015","journal-title":"Scandinavian Journal of Immunology"},{"issue":"4","key":"e_1_2_10_30_1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41574-019-0312-5","article-title":"New Aspects of Vitamin D Metabolism and Action\u2014Addressing the Skin as Source and Target","volume":"16","author":"Bikle D.","year":"2020","journal-title":"Nature Reviews. 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M.","year":"2011","journal-title":"Journal of Investigative Dermatology"},{"key":"e_1_2_10_43_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2021.577792","article-title":"Calcitonin Gene\u2010Related Peptide Upregulates IL\u201017A and IL\u201022 in Gammadelta\u2010T Cells Through the Paracrine Effect of Langerhans Cells on LC\/Gammadelta\u2010T Co\u2010Culture Model","volume":"364","author":"Peng F.","year":"2022","journal-title":"Journal of Neuroimmunology"},{"key":"e_1_2_10_44_1","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.bbi.2017.10.022","article-title":"Chronic Social Stress Ameliorates Psoriasiform Dermatitis Through Upregulation of the Hypothalamic\u2010Pituitary\u2010Adrenal Axis","volume":"68","author":"Vegas O.","year":"2018","journal-title":"Brain, Behavior, and Immunity"},{"issue":"4","key":"e_1_2_10_45_1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.cell.2019.06.022","article-title":"Cutaneous TRPV1(+) Neurons Trigger Protective Innate Type 17 Anticipatory Immunity","volume":"178","author":"Cohen J. 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