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Parallel to a similar study on adults, a systematic review was performed to analyze the efficacy of<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>in the treatment of children and adolescents. All randomized or matched controlled trials (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>) evaluating<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>in any setting with child and adolescent index patients were identified by database searches and cross\u2010references, as well as in existing meta\u2010analyses and reviews. Inclusion criteria were: index patient diagnosed with a<jats:styled-content style=\"fixed-case\">DSM<\/jats:styled-content>\u2010IV or<jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\u201010 listed psychological disorder, or suffering from other clinically relevant conditions, and trial published by<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2011. Studies were analyzed according to their sample, research methodology, interventions applied, and results at end\u2010of\u2010treatment and at follow\u2010up. This article presents findings for internalizing and mixed disorders. Thirty\u2010eight trials were identified, with 33 showing<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>to be efficacious for the treatment of internalizing disorders (including mood disorders, eating disorders, and psychological factors in somatic illness). There is some evidence for<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>being also efficacious in mixed disorders, anxiety disorders, Asperger disorder, and in cases of child neglect. Results were stable across follow\u2010up periods of up to 5\u00a0years. Trials on the efficacy of<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>for externalizing disorders are presented in a second article. There is a sound evidence base for the efficacy of<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>as a treatment for internalizing disorders of child and adolescent patients.<\/jats:p>","DOI":"10.1111\/famp.12041","type":"journal-article","created":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T08:48:54Z","timestamp":1375692534000},"page":"619-652","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["The Efficacy of Systemic Therapy for Internalizing and Other Disorders of Childhood and Adolescence: A Systematic Review of 38 Randomized Trials"],"prefix":"10.1111","volume":"52","author":[{"given":"Ruediger","family":"Retzlaff","sequence":"first","affiliation":[{"name":"Institute for Collaborative Psychosomatic Research and Family Therapy Centre of Psychosocial Medicine Heidelberg University Hospital Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"von Sydow","sequence":"additional","affiliation":[{"name":"Berlin School of Psychology\/Psychologische Hochschule Berlin (PHB) Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Beher","sequence":"additional","affiliation":[{"name":"Department of Sociology University of Bielefeld Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus W.","family":"Haun","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine &amp; Psychosomatics Heidelberg University Hospital Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Schweitzer","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology Centre of Psychosocial Medicine Heidelberg University Hospital Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,5]]},"reference":[{"key":"e_1_2_6_4_1","first-page":"595","volume-title":"Handbook of psychotherapy and behavior change","author":"Alexander J. 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