{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:35:49Z","timestamp":1782516949792,"version":"3.54.5"},"reference-count":72,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,10,27]],"date-time":"2019-10-27T00:00:00Z","timestamp":1572134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Family Process"],"published-print":{"date-parts":[[2020,12]]},"abstract":"This randomized controlled trial (RCT<\/jats:styled-content>) aimed to pilot the newly developed manualized and monitored systemic therapy (ST<\/jats:styled-content>) for social anxiety disorder (SAD<\/jats:styled-content>), as compared to manualized and monitored cognitive behavioral therapy (CBT<\/jats:styled-content>). We conducted a prospective multicenter, assessor\u2010blind pilot RCT<\/jats:styled-content> on 38 outpatients (ICD<\/jats:styled-content> F40.1; Structured Clinical Interview for DSM<\/jats:styled-content> (SCID<\/jats:styled-content>); Liebowitz Social Anxiety Scale, LSAS<\/jats:styled-content>\u2010SR<\/jats:styled-content> >30). The primary outcome was level of social anxiety (LSAS<\/jats:styled-content>\u2010SR<\/jats:styled-content>) at the end of treatment. A total of 252 persons were screened, and 38 patients were randomized and started therapy (CBT<\/jats:styled-content>: 20 patients; ST<\/jats:styled-content>: 18 patients; age: M\u00a0<\/jats:italic>=\u00a0<\/jats:italic>36\u00a0years, SD<\/jats:styled-content><\/jats:italic>\u00a0=\u00a014). Within\u2010group, simple\u2010effect intent\u2010to\u2010treat analyses (ITT<\/jats:styled-content>) showed significant reduction in LSAS<\/jats:styled-content>\u2010SR<\/jats:styled-content> (CBT<\/jats:styled-content>:d<\/jats:italic>\u00a0=\u00a01.04; ST<\/jats:styled-content>:d<\/jats:italic>\u00a0=\u00a01.67), while ITT<\/jats:styled-content> mixed\u2010design ANOVA<\/jats:styled-content> demonstrated the advantage of ST<\/jats:styled-content> (d<\/jats:italic>\u00a0=\u00a00.81). Per\u2010protocol analyses supported these results. Remission based on reliable change indices also demonstrated significant difference (LSAS<\/jats:styled-content>\u2010SR<\/jats:styled-content>: 15% in CBT<\/jats:styled-content>; 39% in ST<\/jats:styled-content>;h<\/jats:italic>: 0.550), supported by blind diagnosticians\u2019 ratings of those who completed therapy (SCID<\/jats:styled-content>; 45% in CBT<\/jats:styled-content>, 78% in ST<\/jats:styled-content>,p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.083). No adverse events were reported. CBT<\/jats:styled-content> and ST<\/jats:styled-content> both reduced social anxiety, supporting patient improvement with the newly developed ST<\/jats:styled-content> for SAD<\/jats:styled-content>; this has yet to be verified in a subsequent confirmatory RCT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/famp.12492","type":"journal-article","created":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T04:18:55Z","timestamp":1572236335000},"page":"1389-1406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Comparing Cognitive Behavioral Therapy and Systemic Therapy for Social Anxiety Disorder: Randomized Controlled Pilot Trial (SOPHO<\/scp>\u2010CBT<\/scp>\/ST<\/scp>)"],"prefix":"10.1111","volume":"59","author":[{"given":"Christina","family":"Hunger","sequence":"first","affiliation":[{"name":"Institute of Medical Psychology Center for Psychosocial Medicine University Hospital Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Hilzinger","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology Center for Psychosocial Medicine University Hospital Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Klewinghaus","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology Center for Psychosocial Medicine University Hospital Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Deusser","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology Center for Psychosocial Medicine University Hospital Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Sander","sequence":"additional","affiliation":[{"name":"Institute of Medical Biometry and Informatics University of Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Mander","sequence":"additional","affiliation":[{"name":"Center for Psychological Psychotherapy University of Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hinrich","family":"Bents","sequence":"additional","affiliation":[{"name":"Center for Psychological Psychotherapy University of Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Ditzen","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology Center for Psychosocial Medicine University Hospital Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Schweitzer","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology Center for Psychosocial Medicine University Hospital Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-859X-9-20"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1545-5300.1988.00371.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa8201_11"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7916(72)90045-6"},{"key":"e_1_2_6_6_1","volume-title":"Milan systemic family therapy","author":"Boscolo L.","year":"1987"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.6.1179"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13060744"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.74.3.568"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.71.6.1058"},{"key":"e_1_2_6_11_1","first-page":"69","volume-title":"Social phobia: Diagnosis, assessment, and treatment","author":"Clark D. 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