{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:00:12Z","timestamp":1755223212149,"version":"3.43.0"},"reference-count":67,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T00:00:00Z","timestamp":1743292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Family Process"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>A significant portion of mothers (pregnant and postpartum) enrolled in U.S. home visiting programs report clinically significant depressive symptoms. Non\u2010violent family conflict precipitates and exacerbates their depressive symptoms. This pilot randomized trial tested the preliminary effectiveness of a family therapy intervention, Resilience Enhancement Skills Training (REST), compared to the standard of care in home\u2010visited mothers with moderate to severe depressive symptoms and moderate to high conflict with family members. A total of 83 mothers and their family members (<jats:italic>N<\/jats:italic>\u2009=\u2009166) were randomized to receive REST or the standard of care. Both interventions were delivered by clinicians using HIPAA\u2010compliant video conferencing technology. Outcomes were assessed by research assistants, blinded to study group assignment, at post\u2010intervention, 3, and 6\u2009months later. Linear mixed\u2010effects models were used to analyze changes in continuous outcomes in mothers and family members, separately. Mixed\u2010effects logistic regression was used to analyze changes in maternal job attainment\/school enrollment. Participants in both study groups showed improvements in outcomes. When compared to standard\u2010of\u2010care participants, REST participants had significantly greater reductions in family conflict (mothers ES\u2009=\u2009\u22121.19, family members ES\u2009=\u2009\u22120.77), maternal depressive symptoms (ES\u2009=\u2009\u22120.96) and co\u2010occurring anxiety symptoms (ES\u2009=\u2009\u22120.59), and greater increases in family cohesion (mothers ES\u2009=\u20090.99, family members ES\u2009=\u20090.94) and maternal job attainment\/school enrollment (ES\u2009=\u20090.70). The results highlight the value of family therapy for the treatment of moderate to severe depressive symptoms in home\u2010visited mothers, including those with co\u2010occurring moderate to severe anxiety symptoms.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> Registered in <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> on 02\/04\/2021. NCT04741776 <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04741776\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04741776<\/jats:ext-link><\/jats:p>","DOI":"10.1111\/famp.70032","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T20:13:10Z","timestamp":1743451990000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preliminary Effectiveness of Family Therapy for Perinatal Depressive Symptoms: Results From a Pilot Randomized Trial"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8701-1209","authenticated-orcid":false,"given":"Fallon","family":"Cluxton\u2010Keller","sequence":"first","affiliation":[{"name":"Department of Psychiatry Geisel School of Medicine at Dartmouth  Lebanon New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4549-879X","authenticated-orcid":false,"given":"Haiyi","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science Geisel School of Medicine at Dartmouth  Hanover New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2877-2398","authenticated-orcid":false,"given":"Mark T.","family":"Hegel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Geisel School of Medicine at Dartmouth  Lebanon New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8762-9893","authenticated-orcid":false,"given":"Craig L.","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Geisel School of Medicine at Dartmouth  Lebanon New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9973-2142","authenticated-orcid":false,"given":"Martha L.","family":"Bruce","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Geisel School of Medicine at Dartmouth  Lebanon New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1037\/fam0000888"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beth.2013.01.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2013.03.003"},{"volume-title":"Manual for the Beck Depression Inventory\u2010II","year":"1996","author":"Beck A. 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