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Yet, little is known about how different acute and chronic conditions distinctly impact both partners' well\u2010being. This study analyzed the reciprocal associations between different illnesses on life satisfaction and relationship satisfaction in partnerships. Based on data from the Family Demographic Panel (FReDA), 14,426 people were analyzed in a two\u2010stage analysis process. In the first step, a Welch\u2010ANOVA examined disease\u2010specific differences in life satisfaction as a function of partnership status, focusing on the well\u2010being of the ill individual. In the second step, an extended Actor\u2013Partner Interdependence Model (APIM) was applied to partnered dyads, shifting the focus to the healthy partner and analyzing how the illness of one partner and relational factors are associated with the partner's relationship and life satisfaction. The results revealed substantial crossover effects, with consistent partnership\u2010related patterns across illness types. Disease severity and duration were negatively associated with relationship satisfaction, whereas intimacy and constructive conflict resolution emerged as universal protective factors. These findings underscore the relevance of a systemic perspective in healthcare and show the need for partnership\u2010oriented interventions.<\/jats:p>","DOI":"10.1111\/famp.70129","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:51:01Z","timestamp":1770990661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Turning Everything Upside Down: The Impact of Illness on Romantic Relationships\u2014A\n                    <scp>SEM<\/scp>\n                    \u2010Based Actor\u2010Partner Interdependence Model"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7946-0960","authenticated-orcid":false,"given":"Franziska","family":"Reinhardt","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Integrated Psychosomatic Medicine University Hospital Wuerzburg  Wuerzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8030-1182","authenticated-orcid":false,"given":"Imad","family":"Maatouk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Integrated Psychosomatic Medicine University Hospital Wuerzburg  Wuerzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127\u2010003\u20100680\u2010x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2017.1390612"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.589621"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.FCH.0000290543.48576.cf"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/07347332.2016.1195901"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3200"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29009"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033\u20102909.133.6.920"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2021.624609"},{"issue":"1","key":"e_1_2_9_11_1","first-page":"34","article-title":"A Systemic\u2010Transactional Conceptualization of Stress and Coping in Couples","volume":"54","author":"Bodenmann G.","year":"1995","journal-title":"Swiss Journal of Psychology"},{"key":"e_1_2_9_12_1","first-page":"2","volume-title":"Couples Coping With Stress: A Cross\u2010Cultural Perspective","author":"Bodenmann G.","year":"2016"},{"key":"e_1_2_9_13_1","volume-title":"FReDA\u2014The German Family Demography Panel Study (Study No. ZA7777; Data File Version 3.0.0)","author":"Bujard M.","year":"2023"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2019.04.001"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751\u20109004.2011.00372.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200205000-00012"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.12968\/gasn.2014.12.1.16"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008483\u2010199611000\u201000006"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcnurse.2011.01.006"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/famp.12604"},{"key":"e_1_2_9_21_1","volume-title":"An R Companion to Applied Regression","author":"Fox J.","year":"2019"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.JCN.0000338928.51093.40"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000995"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1090198102251030"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327965PLI1303_04"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/diaspect.14.1.33"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010006\u20100148\u20100"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000316"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copsyc.2021.07.012"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/10705519909540118"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010014\u20109983\u20103"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.4324\/9781351168366"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010015\u20101169\u20102"},{"key":"e_1_2_9_34_1","volume-title":"Dyadic Data Analysis","author":"Kenny D. 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