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Carbamazepine was used as a positive control. Methylphenidate (5\u00a0mg\/kg, s.c.) increased open\u2010field locomotion, and phenytoin (5\u201310\u00a0mg\/kg, i.p.) and carbamazepine (20\u00a0mg\/kg, i.p.) blocked this effect. Veratrine (0.4\u00a0mg\/kg, s.c.) pretreatment reversed the effects of phenytoin (10\u00a0mg\/kg, i.p.) and carbamazepine (20\u00a0mg\/kg, i.p.). Phenytoin (1\u201350\u00a0mg\/kg, i.p.) and carbamazepine (10\u201320\u00a0mg\/kg i.p.) alone did not change spontaneous locomotor activity. These results indicate that voltage\u2010gated sodium channels play an important role in antimanic\u2010like effects of phenytoin and carbamazepine on psychostimulant\u2010induced hyperlocomotion model.<\/jats:p>","DOI":"10.1111\/fcp.12022","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T13:20:44Z","timestamp":1361798444000},"page":"650-655","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The antimanic\u2010like effect of phenytoin and carbamazepine on methylphenidate\u2010induced hyperlocomotion: role of voltage\u2010gated sodium channels"],"prefix":"10.1111","volume":"27","author":[{"given":"Denise A.G.","family":"Tonelli","sequence":"first","affiliation":[{"name":"Division of Biological Sciences Department of Pharmacology Universidade Federal do Paran\u00e1 Centro Polit\u00e9cnico C.P. 19031 Curitiba Paran\u00e1 81540\u2010990 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