{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:17:59Z","timestamp":1790702279177,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T00:00:00Z","timestamp":1378339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although diphenhydramine has been shown to produce longer duration of spinal block than lidocaine, few studies disclose its skin infiltrative anesthesia when compared with a long\u2010lasting local anesthetic, bupivacaine. The purpose of this study was to investigate whether diphenhydramine elicited cutaneous analgesia in comparison with bupivacaine. After inhibition of cutaneous trunci muscle reflex via subcutaneous injection of drugs in rats, we examined the local anesthetic effect of diphenhydramine and bupivacaine as infiltrative cutaneous analgesia in a dose\u2010dependent fashion. We showed that diphenhydramine, as well as bupivacaine displayed a dose\u2010dependent cutaneous analgesia in response to dorsal cutaneous noxious stimuli. The relative potency (50% effective dose) was bupivacaine (0.023 [0.013\u20130.035]%)\u00a0&gt;\u00a0diphenhydramine (0.078 [0.068\u20130.091]%; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). On an equipotent basis, diphenhydramine had a similar duration of action to bupivacaine. Neither local injection of saline nor intraperitoneal administration of a large dose of diphenhydramine or bupivacaine produced cutaneous analgesia (data not shown). We conclude that diphenhydramine is less potent than bupivacaine at producing cutaneous analgesia. At equipotent doses for infiltrative cutaneous analgesia, the duration of action of diphenhydramine is equal to that of bupivacaine.<\/jats:p>","DOI":"10.1111\/fcp.12048","type":"journal-article","created":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T06:29:02Z","timestamp":1376461742000},"page":"439-444","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Diphenhydramine produces local cutaneous analgesia in response to dorsal skin noxious stimuli in the rat"],"prefix":"10.1111","volume":"28","author":[{"given":"Yu\u2010Wen","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Physical Therapy Graduate Institute of Rehabilitation Science China Medical University 40402 Taichung Taiwan"},{"name":"Department of Medical Research Chi\u2010Mei Medical Center Yong Kang 71004 Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jann\u2010Inn","family":"Tzeng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Chi\u2010Mei Medical Center Yong Kang 71004 Tainan Taiwan"},{"name":"Department of Food Sciences and Technology Chia Nan University of Pharmacy and Sciences Jen\u2010Te 71710 Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010Yun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Graduate Institute of Rehabilitation Science China Medical University 40402 Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhi\u2010Joung","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Research Chi\u2010Mei Medical Center Yong Kang 71004 Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Chung","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Physical Therapy Department of Physical Medicine and Rehabilitation Cheng Hsin General Hospital 112 Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Hsia","family":"Hung","sequence":"additional","affiliation":[{"name":"Institute &amp; Department of Physical Therapy National Cheng Kung University 701 Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2010.550583"},{"key":"e_1_2_7_3_1","first-page":"37","article-title":"Diphenhydramine as an alternative local anesthetic agent","volume":"2","author":"Pavlidakey P.G.","year":"2009","journal-title":"J. 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