{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:31:22Z","timestamp":1696368682566},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,1,5]],"date-time":"2014-01-05T00:00:00Z","timestamp":1388880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Selcuk University Scientific Research Center","award":["11102047"],"award-info":[{"award-number":["11102047"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2014,12]]},"abstract":"Abstract<\/jats:title>The aim of this study is to evaluate the effects of intra\u2010articular levobupivacaine on rabbit knee articular cartilage and certain biochemical parameters in the blood. A total of 24 N<\/jats:styled-content>ew Z<\/jats:styled-content>ealand rabbits were included to study. Blood sampling was carried out in all animals on the first day, then the subjects were randomly allocated either to the control group (Group\u00a0C, n<\/jats:italic>\u00a0=\u00a09) or to the levobupivacaine group (Group\u00a0L, n<\/jats:italic>\u00a0=\u00a015). Group\u00a0C underwent each two intra\u2010articular injections of saline, 0.25\u00a0mL into the right knee and 0.50\u00a0mL into the left one. Group L was injected 0.25\u00a0mL (1.25\u00a0mg) of levobupivacaine into the right knee and 0.50\u00a0mL (2.5\u00a0mg) into the left one. The groups were divided randomly into three. Tissue and blood samples for histologic and biochemical examination were collected from G<\/jats:styled-content>roups C<\/jats:styled-content>1 and L<\/jats:styled-content>1 on the first, C<\/jats:styled-content>2 and L<\/jats:styled-content>2 on the second, and C<\/jats:styled-content>3 and L<\/jats:styled-content>3 on the tenth day of the study. Interleukin\u20101\u03b2 (IL<\/jats:styled-content>\u20101 \u03b2), interleukin\u20106 (IL<\/jats:styled-content>\u20106), tumor necrosis factor\u2010alpha (TNF<\/jats:styled-content>\u2010\u03b1), and C<\/jats:styled-content>\u2010reactive protein (CRP<\/jats:styled-content>) levels were analyzed. No statistically significant differences could be detected when comparing either left or right joints within the same groups and with G<\/jats:styled-content>roup C<\/jats:styled-content> and L<\/jats:styled-content> (P<\/jats:italic>\u00a0>\u00a00.05). Significant elevations of biochemical parameters were found in G<\/jats:styled-content>roup C<\/jats:styled-content>. It is concluded that levobupivacaine does not lead to significant histologic changes in rabbit articular cartilage. Significant elevations of biochemical parameters being generally found in the C G<\/jats:styled-content>roup, it is thought that such elevations are not linked to levobupivacaine. Intra\u2010articular levobupivacaine may be a safe alternative for use in post\u2010operative analgesia.<\/jats:p>","DOI":"10.1111\/fcp.12062","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T17:06:22Z","timestamp":1387213582000},"page":"627-632","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Investigation of effects of levobupivacaine injection to rabbit knee joint on histopathologic changes of joint cartilage tissue and changes of serum biochemical parameters"],"prefix":"10.1111","volume":"28","author":[{"given":"Hasan","family":"Ozkaya","sequence":"first","affiliation":[{"name":"Anesthesiology and Reanimation Department Meram Medical School 42080 Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuba Berra","family":"Sar\u0131ta\u015f","sequence":"additional","affiliation":[{"name":"Anesthesiology and Reanimation Department Meram Medical School 42080 Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zulf\u0131kar Kad\u0131r","family":"Sar\u0131ta\u015f","sequence":"additional","affiliation":[{"name":"Surgery Department Veterinary Medicine Faculty Afyonkarahisar University 03200 Afyonkarahisar Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Musa","family":"Korkmaz","sequence":"additional","affiliation":[{"name":"Surgery Department Veterinary Medicine Faculty Afyonkarahisar University 03200 Afyonkarahisar Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alper","family":"Sev\u0131ml\u0131","sequence":"additional","affiliation":[{"name":"Pathology Department Veterinary Medicine Faculty Afyonkarahisar University 03200 Afyonkarahisar Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130dris","family":"Mehmetoglu","sequence":"additional","affiliation":[{"name":"Biochemistry Department Meram Medical School 42080 Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eeref","family":"Otelc\u0131oglu","sequence":"additional","affiliation":[{"name":"Anesthesiology and Reanimation Department Meram Medical School 42080 Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.8.6.861"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2006.05.006"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2006.06.006"},{"key":"e_1_2_6_5_1","first-page":"629","article-title":"A comparison of analgesic effect of intra\u2010articular levobupivacaine with bupivacaine following knee arthroscopy","volume":"30","author":"Karaman Y.","year":"2009","journal-title":"Saudi Med. 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