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Some cases of abuse and misuse, especially associated with various benzodiazepines (<jats:styled-content style=\"fixed-case\">BZD<\/jats:styled-content>s), have been described, and a previous study has shown that<jats:styled-content style=\"fixed-case\">BZD<\/jats:styled-content>s increase the sedative effect of<jats:styled-content style=\"fixed-case\">BPN<\/jats:styled-content>and decrease its anxiogenic properties. To investigate the reward effect that may lead to the abusive combination of<jats:styled-content style=\"fixed-case\">BPN<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">BZD<\/jats:styled-content>, we studied the influence of different doses of three<jats:styled-content style=\"fixed-case\">BZD<\/jats:styled-content>s extensively used with<jats:styled-content style=\"fixed-case\">BPN<\/jats:styled-content>by drug addicts on conditioned place preference behavior in mice.<jats:styled-content style=\"fixed-case\">BPN<\/jats:styled-content>(0.3, 1, 3\u00a0mg\/kg) was injected subcutaneously into male mice alone or in combination with a<jats:styled-content style=\"fixed-case\">BZD<\/jats:styled-content>administered intraperitoneally: dipotassium clorazepate (<jats:styled-content style=\"fixed-case\">CRZ<\/jats:styled-content>; 1, 4, 16\u00a0mg\/kg), diazepam (<jats:styled-content style=\"fixed-case\">DAZ<\/jats:styled-content>; 0.5, 1, 5\u00a0mg\/kg), or bromazepam (<jats:styled-content style=\"fixed-case\">BMZ<\/jats:styled-content>; 0.5, 1, 3\u00a0mg\/kg). Amphetamine (8\u00a0mg\/kg) was used as a reference drug. Reward effects of<jats:styled-content style=\"fixed-case\">BPN<\/jats:styled-content>alone or in combination were measured in a conditioned place preference paradigm using an unbiased procedure. Our results showed that groups treated with<jats:styled-content style=\"fixed-case\">BPN<\/jats:styled-content>associated with different doses of diazepam and clorazepate, but not bromazepam, spent significantly more time in the drug\u2010paired compartment compared to the group treated with<jats:styled-content style=\"fixed-case\">BPN<\/jats:styled-content>alone. Our study shows that joint consumption of diazepam and clorazepate, but not bromazepam, can increase the reward properties of<jats:styled-content style=\"fixed-case\">BPN<\/jats:styled-content>alone in mice. These results could help to explain the use of this type of drug combination in the drug addict population.<\/jats:p>","DOI":"10.1111\/fcp.12072","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T06:11:17Z","timestamp":1394604677000},"page":"681-689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Benzodiazepines increase the reward effects of buprenorphine in a conditioned place preference test in the mouse"],"prefix":"10.1111","volume":"28","author":[{"given":"Lin\u2010Lin","family":"Ma","sequence":"first","affiliation":[{"name":"Normandie University CS 14032 Cedex 5 Caen France"},{"name":"UCBN COMETE UFR de M\u00e9decine Avenue de la C\u00f4te de Nacre CS 14032 Cedex 5 Caen France"},{"name":"Inserm U 1075 COMETE UFR de M\u00e9decine Avenue de la C\u00f4te de Nacre CS 14032 Cedex 5 Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Freret","sequence":"additional","affiliation":[{"name":"Normandie University CS 14032 Cedex 5 Caen France"},{"name":"UCBN Groupe M\u00e9moire et Plasticit\u00e9 comportementale (GMPc) EA 4259 UFR des Sciences Pharmaceutiques, Boulevard Becquerel 14032 Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Lange","sequence":"additional","affiliation":[{"name":"CHU de Caen, Service de Pharmacologie Avenue de la C\u00f4te de Nacre 14033 Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Bourgine","sequence":"additional","affiliation":[{"name":"Normandie University CS 14032 Cedex 5 Caen France"},{"name":"UCBN COMETE UFR de M\u00e9decine Avenue de la C\u00f4te de Nacre CS 14032 Cedex 5 Caen France"},{"name":"Inserm U 1075 COMETE UFR de M\u00e9decine Avenue de la C\u00f4te de Nacre CS 14032 Cedex 5 Caen France"},{"name":"CHU de Caen, Service de Pharmacologie Avenue de la C\u00f4te de Nacre 14033 Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Coquerel","sequence":"additional","affiliation":[{"name":"Normandie University CS 14032 Cedex 5 Caen France"},{"name":"UCBN COMETE UFR de M\u00e9decine Avenue de la C\u00f4te de Nacre CS 14032 Cedex 5 Caen France"},{"name":"Inserm U 1075 COMETE UFR de M\u00e9decine Avenue de la C\u00f4te de Nacre CS 14032 Cedex 5 Caen France"},{"name":"CHU de Caen, Service de Pharmacologie Avenue de la C\u00f4te de Nacre 14033 Caen France"},{"name":"Centres r\u00e9gionaux de pharmacovigilance et d'addictovigilance CHU Caen 14033 Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Lelong\u2010Boulouard","sequence":"additional","affiliation":[{"name":"Normandie University CS 14032 Cedex 5 Caen France"},{"name":"UCBN COMETE UFR de M\u00e9decine Avenue de la C\u00f4te de Nacre CS 14032 Cedex 5 Caen France"},{"name":"Inserm U 1075 COMETE UFR de M\u00e9decine Avenue de la C\u00f4te de Nacre CS 14032 Cedex 5 Caen France"},{"name":"CHU de Caen, Service de Pharmacologie Avenue de la C\u00f4te de Nacre 14033 Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2012.03.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/11597520-000000000-00000"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159043359477"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10550490600626606"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2515\/therapie:2007061"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/22.6.430"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199912002-00002"},{"issue":"2","key":"e_1_2_7_9_1","first-page":"28","article-title":"Benzodiazepine use, abuse, and dependence","volume":"66","author":"O'Brien C.P.","year":"2005","journal-title":"J. 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