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In our study, we attempted to investigate the role of 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>3 receptors in scratching behavior due to intradermal serotonin injection. Intradermal injection of serotonin (14.1\u2013235\u00a0nmol\/site) into the nape of the neck of mice was performed to elicit itch. Scratching behavior was evaluated by measuring the number of bouts during 60\u00a0min after injection. We evaluated the effect of intraperitoneal pretreatment with ondansetron and tropisetron (0.1, 0.3, and 1\u00a0mg\/kg) on itch induced by serotonin. Also, intradermal ondansetron and tropisetron at doses 50, 100, and 200\u00a0nmol\/site were concurrently administrated with serotonin. Serotonin produced a significant enhancement in scratching at dose 141\u00a0nmol\/site. Concurrent administration of ondansetron (50, 100, and 200\u00a0nmol\/site) and tropisetron (100 and 200\u00a0nmol\/site) with serotonin reduced scratching activity compared to the animals that only received serotonin. Also, pretreatment with intraperitoneal ondansetron and tropisetron (0.3 and 1\u00a0mg\/kg) 30\u00a0min before serotonin attenuated the itch response. We showed that the scratching induced by intradermal serotonin is mediated by 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>3 receptors subtype. It can be concluded that 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>3 may play a role in mediating serotonin\u2010associated itch responses, and we introduce 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>3 receptors as possible targets for antipruritic agents.<\/jats:p>","DOI":"10.1111\/fcp.12112","type":"journal-article","created":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T01:49:42Z","timestamp":1424828982000},"page":"310-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["5\u2010<scp>HT<\/scp>3 receptors antagonists reduce serotonin\u2010induced scratching in mice"],"prefix":"10.1111","volume":"29","author":[{"given":"Sattar","family":"Ostadhadi","sequence":"first","affiliation":[{"name":"Experimental Medicine Research Center Tehran University of Medical Sciences Tehran Iran"},{"name":"Department of Pharmacology School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nastaran","family":"Kordjazy","sequence":"additional","affiliation":[{"name":"Experimental Medicine Research Center Tehran University of Medical Sciences Tehran Iran"},{"name":"Department of Pharmacology School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arya","family":"Haj\u2010Mirzaian","sequence":"additional","affiliation":[{"name":"Experimental Medicine Research Center Tehran University of Medical Sciences Tehran Iran"},{"name":"Department of Pharmacology School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parvin","family":"Mansouri","sequence":"additional","affiliation":[{"name":"Skin and Stem cell Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad Reza","family":"Dehpour","sequence":"additional","affiliation":[{"name":"Experimental Medicine Research Center Tehran University of Medical Sciences Tehran Iran"},{"name":"Department of Pharmacology School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1950"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700231"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2005.00036.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07430.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcg002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(99)00070-X"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050213"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.283.6286.277"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)00145-5"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(00)70251-4"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(01)00746-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.049239"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91178-O"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.32887"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405263302117"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00115550-200009000-00017"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000044967"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.1990.tb00482.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12082"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881109348161"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550152572868"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.178"},{"key":"e_1_2_8_24_1","first-page":"5","article-title":"Four possible itching pathways related to the TRPV1 channel, histamine, PAR\u20102 and serotonin","volume":"20","author":"Nakagawa H.","year":"2013","journal-title":"Malays. 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