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In this study, we assessed whether the oestrogen receptor antagonist fulvestrant (F) improves cirrhosis\u2010related lung abnormalities. Cirrhosis was induced in rats by chronic bile duct ligation (<jats:styled-content style=\"fixed-case\">CBDL<\/jats:styled-content>). Four groups were studied: <jats:styled-content style=\"fixed-case\">CBDL<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CBDL<\/jats:styled-content>+F, sham, and sham+F. Histological, immunohistochemical, and Western blot analyses were performed on lung samples. In the lung, the endothelial <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> synthase and the nitrotyrosine protein expressions were increased in <jats:styled-content style=\"fixed-case\">CBDL<\/jats:styled-content> as compared to sham rats. Both parameters were significantly reduced by fulvestrant in the <jats:styled-content style=\"fixed-case\">CBDL<\/jats:styled-content> rats. Surprisingly, the level of <jats:styled-content style=\"fixed-case\">pVASP<\/jats:styled-content> (an indirect marker of <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> formation and action) was decreased in <jats:styled-content style=\"fixed-case\">CBDL<\/jats:styled-content> rats, and fulvestrant had no effect on this parameter. The level of the vascular endothelial growth factor, the diameter of small lung vessels, and the number of macrophages were increased in <jats:styled-content style=\"fixed-case\">CBDL<\/jats:styled-content> lungs in comparison with sham lungs, and these parameters were unaffected by fulvestrant treatment. In conclusion, fulvestrant may not be relevant to improve lung abnormalities in cirrhosis because <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> may not be biologically active and because key events contributing to the lung abnormalities are not affected by fulvestrant.<\/jats:p>","DOI":"10.1111\/fcp.12114","type":"journal-article","created":{"date-parts":[[2015,3,7]],"date-time":"2015-03-07T15:13:18Z","timestamp":1425741198000},"page":"269-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of the oestrogen receptor antagonist fulvestrant on the cirrhotic rat lung"],"prefix":"10.1111","volume":"29","author":[{"given":"Monique","family":"Oswald\u2010Mammosser","sequence":"first","affiliation":[{"name":"Service de Physiologie et d'Explorations Fonctionnelles P\u00f4le de Pathologie Thoracique H\u00f4pitaux Universitaires de Strasbourg et EA 3072 Facult\u00e9 de M\u00e9decine 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