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The trial's goal was to investigate the activity of <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ip <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> in mice exposed to corticosterone\u2010induced chronic depression model. Swiss female mice, 22\u201325\u00a0g, were distributed in following experimental groups: control group (vehicle1: saline containing 0.1% dimethyl sulfoxide and 0.1% <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>ween\u201080, <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>+ vehicle 2: distilled water emulsified with 2% <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>ween\u201080, <jats:styled-content style=\"fixed-case\">PO<\/jats:styled-content>); stressed group (corticosterone, 20\u00a0mg\/kg, <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>, + vehicle 2, orally); Rip <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> group (50\u00a0mg\/kg, orally); and fluvoxamine (<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>lu) group (50\u00a0mg\/kg, orally). The mice were exposed to the behavioral tests, and posteriorly, <jats:styled-content style=\"fixed-case\">Brain\u2010derived neurotrophic factor<\/jats:styled-content> protein levels were assessed in hippocampal samples. Statistical analysis of the data was performed by one\u2010way <jats:sc>anova<\/jats:sc>, followed by <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ewman\u2013<jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>euls test. Both administrations of <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ip <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>lu significantly reduced the immobility time in tail suspension and forced swimming tests after 21\u00a0days without affecting locomotor function. There was also an increase in <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> protein levels in the mice hippocampus. These findings further support the hypothesis that <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ip <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> could be a new pharmacological target for the treatment of mood disorders.<\/jats:p>","DOI":"10.1111\/fcp.12120","type":"journal-article","created":{"date-parts":[[2015,4,4]],"date-time":"2015-04-04T08:09:47Z","timestamp":1428134987000},"page":"394-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Subchronic administration of riparin <scp>III<\/scp> induces antidepressive\u2010like effects and increases <scp>BDNF<\/scp> levels in the mouse hippocampus"],"prefix":"10.1111","volume":"29","author":[{"given":"Auriana S.","family":"Vasconcelos","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology Medicine College Federal University of Ceara Rua Cel Nunes de Melo 1127 60430\u2010270 Fortaleza Ceara Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris C.M.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Medicine College Federal University of Ceara Rua Cel Nunes de Melo 1127 60430\u2010270 Fortaleza Ceara Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura T.M.","family":"Vidal","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Medicine College Federal University of Ceara Rua Cel Nunes de Melo 1127 60430\u2010270 Fortaleza Ceara Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel C.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Medicine College Federal University of Ceara Rua Cel Nunes de Melo 1127 60430\u2010270 Fortaleza Ceara Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley J.C.","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutics Technology Federal University of Paraiba Caixa Postal 5009 58051\u2010970 Jo\u00e3o Pessoa Paraiba PB Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M.","family":"Barbosa\u2010Filho","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutics Technology Federal University of Paraiba Caixa Postal 5009 58051\u2010970 Jo\u00e3o Pessoa Paraiba PB Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silv\u00e2nia M.M.","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Medicine College Federal University of Ceara Rua Cel Nunes de Melo 1127 60430\u2010270 Fortaleza Ceara Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta M.","family":"de Fran\u00e7a Fonteles","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Medicine College Federal University of Ceara Rua Cel Nunes de Melo 1127 60430\u2010270 Fortaleza Ceara Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle M.","family":"Gaspar","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Medicine College Federal University of Ceara Rua Cel Nunes de Melo 1127 60430\u2010270 Fortaleza Ceara Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisca C.F.","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Medicine College Federal University of Ceara Rua Cel Nunes de Melo 1127 60430\u2010270 Fortaleza Ceara Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,24]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization.Depression. 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