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In contrast,<jats:styled-content style=\"fixed-case\">ACEA<\/jats:styled-content>(2.5\u00a0mg\/kg) had no significant impact on the anticonvulsant potency of clobazam and lacosamide in the mouse maximal electroshock\u2010induced seizure model. On the other hand,<jats:styled-content style=\"fixed-case\">ACEA<\/jats:styled-content>(2.5\u00a0mg\/kg) did not affect acute adverse effects of clobazam, lacosamide or pregabalin, and the median toxic doses (<jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content><jats:sub>50<\/jats:sub>) for the studied anti\u2010epileptic drugs in combination with<jats:styled-content style=\"fixed-case\">ACEA<\/jats:styled-content>did not differ from the<jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content><jats:sub>50<\/jats:sub>values as determined for the drugs administered alone in the chimney test. In conclusion,<jats:styled-content style=\"fixed-case\">ACEA<\/jats:styled-content>ameliorates the pharmacological profile of pregabalin, when considering both the anticonvulsant and the acute adverse effects of the drug in preclinical study on animals. The combination of pregabalin with<jats:styled-content style=\"fixed-case\">ACEA<\/jats:styled-content>can be of pivotal importance for patients with epilepsy as a potentially advantageous combination if the results from this study translate into clinical settings.<\/jats:p>","DOI":"10.1111\/fcp.12123","type":"journal-article","created":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T14:40:38Z","timestamp":1429627238000},"page":"382-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Influence of arachidonyl\u20102\u2032\u2010chloroethylamide, a selective cannabinoid<scp>CB<\/scp>1 receptor agonist, on the anticonvulsant and acute side\u2010effect potentials of clobazam, lacosamide, and pregabalin in the maximal electroshock\u2010induced seizure model and chimney test in 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