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We also investigated whether ACE<\/jats:styled-content>i might thereby improve atrial natriuretic peptide (ANP<\/jats:styled-content>) efficiency. We studied renal cortical PDE<\/jats:styled-content>1\u20105 isozyme activities in sham (SH<\/jats:styled-content>)\u2010operated, MI<\/jats:styled-content> rats and in MI<\/jats:styled-content> rats treated with perindopril (ACE<\/jats:styled-content>i) 1\u00a0month after coronary artery ligation. Circulating atrial natriuretic peptide (ANP<\/jats:styled-content>), its second intracellular messenger cyclic guanosine monophosphate (cGMP<\/jats:styled-content>) and cGMP<\/jats:styled-content>\/ANP<\/jats:styled-content> ratio were also determined. Cortical cGMP<\/jats:styled-content>\u2010PDE<\/jats:styled-content>2 (80.3 vs. 65.1\u00a0pmol\/min\/mg) and cGMP<\/jats:styled-content>\u2010PDE<\/jats:styled-content>1 (50.7 vs. 30.1\u00a0pmol\/min\/mg), and cAMP<\/jats:styled-content>\u2010PDE<\/jats:styled-content>2 (161 vs. 104.1\u00a0pmol\/min\/mg) and cAMP<\/jats:styled-content>\u2010PDE<\/jats:styled-content>4 (307.5 vs. 197.2\u00a0pmol\/min\/mg) activities were higher in MI<\/jats:styled-content> than in SH<\/jats:styled-content> rats. Despite increased ANP<\/jats:styled-content> plasma level, ANP<\/jats:styled-content> efficiency tended to be decreased in MI<\/jats:styled-content> compared to SH<\/jats:styled-content> rats. Perindopril restored PDE<\/jats:styled-content> activities and tended to improve ANP<\/jats:styled-content> efficiency in MI<\/jats:styled-content> rats. One month after coronary ligation, perindopril treatment of MI<\/jats:styled-content> rats prevents the increase in renal cortical PDE<\/jats:styled-content> activities. This may contribute to increase renal ANP<\/jats:styled-content> efficiency in MI rats.<\/jats:p>","DOI":"10.1111\/fcp.12124","type":"journal-article","created":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T08:08:46Z","timestamp":1430813326000},"page":"352-361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Angiotensin\u2010converting enzyme inhibition prevents myocardial infarction\u2010induced increase in renal cortical cGMP<\/scp> and cAMP<\/scp> phosphodiesterase activities"],"prefix":"10.1111","volume":"29","author":[{"given":"Fran\u00e7ois","family":"Clauss","sequence":"first","affiliation":[{"name":"EA3072 Translational Medicine Federation Institute of Physiology University of Strasbourg 67000 Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Charloux","sequence":"additional","affiliation":[{"name":"EA3072 Translational Medicine Federation Institute of Physiology University of Strasbourg 67000 Strasbourg France"},{"name":"Department of Physiology and Functional Explorations P\u00f4le de Pathologie thoracique CHRU H\u00f4pitaux Universitaires BP 426 67091 Strasbourg Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Piquard","sequence":"additional","affiliation":[{"name":"EA3072 Translational Medicine Federation Institute of Physiology University of Strasbourg 67000 Strasbourg France"},{"name":"Department of Physiology and Functional Explorations P\u00f4le de Pathologie thoracique CHRU H\u00f4pitaux Universitaires BP 426 67091 Strasbourg Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Doutreleau","sequence":"additional","affiliation":[{"name":"EA3072 Translational Medicine Federation Institute of Physiology University of Strasbourg 67000 Strasbourg France"},{"name":"Department of Physiology and Functional Explorations P\u00f4le de Pathologie thoracique CHRU H\u00f4pitaux Universitaires BP 426 67091 Strasbourg Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samy","family":"Talha","sequence":"additional","affiliation":[{"name":"EA3072 Translational Medicine Federation Institute of Physiology University of Strasbourg 67000 Strasbourg France"},{"name":"Department of Physiology and Functional Explorations P\u00f4le de Pathologie thoracique CHRU H\u00f4pitaux Universitaires BP 426 67091 Strasbourg Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joffrey","family":"Zoll","sequence":"additional","affiliation":[{"name":"EA3072 Translational Medicine Federation Institute of Physiology University of Strasbourg 67000 Strasbourg France"},{"name":"Department of Physiology and Functional Explorations P\u00f4le de Pathologie thoracique CHRU H\u00f4pitaux Universitaires BP 426 67091 Strasbourg Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Lugnier","sequence":"additional","affiliation":[{"name":"CNRS\u2010UMR 7213 Biophotonic and Pharmacology 74 route du Rhin BP 24 67401 Illkirch France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Geny","sequence":"additional","affiliation":[{"name":"EA3072 Translational Medicine Federation Institute of Physiology University of Strasbourg 67000 Strasbourg France"},{"name":"Department of Physiology and Functional Explorations P\u00f4le de Pathologie thoracique CHRU H\u00f4pitaux Universitaires BP 426 67091 Strasbourg Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,25]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"235","article-title":"Novel therapeutic directions for the natriuretic peptides in cardiovascular diseases: what's on the horizon","volume":"48","author":"Burnett J.C.","year":"2006","journal-title":"J. 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