{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:22:07Z","timestamp":1761513727051},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T00:00:00Z","timestamp":1450828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed at detecting a signal of an increased risk of cancer in patients treated with <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> inhibitor (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i) and nonbiological immunosuppressant (<jats:styled-content style=\"fixed-case\">NBIS<\/jats:styled-content>)<jats:bold>,<\/jats:bold> compared with <jats:styled-content style=\"fixed-case\">NBIS<\/jats:styled-content> alone for autoimmune diseases. Secondly, we aimed at comparing this risk between the different <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>is. We conducted a disproportionality analysis (case\/noncase study) from the French National PharmacoVigilance Database. We selected all the reports of serious adverse drug reactions from 2000 to 2010 in patients treated with <jats:styled-content style=\"fixed-case\">NBIS<\/jats:styled-content> for labeled indications of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i. Cases were all the reports of cancer that occurred after a minimal 3\u2010month exposure to <jats:styled-content style=\"fixed-case\">NBIS<\/jats:styled-content>. Noncases were all the other reports. We searched for exposure to <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i and calculated reporting odds ratios (<jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content>s), stratified by condition and type of cancer and adjusted by age, gender, history of cancer, type of <jats:styled-content style=\"fixed-case\">NBIS<\/jats:styled-content> and year of reporting. Of the 1918 reports included in the study population, 217 were cases (135 solid and 82 blood cancers). A safety signal was found in rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) (<jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content>: 5.43, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>[3.52\u20138.38]) particularly for nonmelanoma skin cancer (<jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content>) (20.17[2.49\u2013163.36]), and in psoriasis\/psoriatic arthritis (3.45[1.09\u201310.92]). No signal was found in inflammatory bowel diseases (<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>) and ankylosing spondylitis, whatever the type of cancer. There was no difference between <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>is. This study puts the argument of an increased risk of cancer (particularly <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content>) in patients with rheumatoid arthritis exposed to <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i and <jats:styled-content style=\"fixed-case\">NBIS<\/jats:styled-content> compared with <jats:styled-content style=\"fixed-case\">NBIS<\/jats:styled-content> alone, but not in <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> and ankylosing spondylitis patients. No signal was detected for melanoma potentially related to the lack of power. The signal seems similar whatever the <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i.<\/jats:p>","DOI":"10.1111\/fcp.12171","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T07:47:00Z","timestamp":1448437620000},"page":"162-171","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Tumor necrosis factor inhibitors added to nonbiological immunosuppressants vs. nonbiological immunosuppressants alone: a different signal of cancer risk according to the condition. A disproportionality analysis in a nationwide pharmacovigilance database"],"prefix":"10.1111","volume":"30","author":[{"given":"Layla","family":"Saliba","sequence":"first","affiliation":[{"name":"Service de Pharmacologie Medicale et Clinique Centre Midi\u2010Pyrenees de PharmacoVigilance de Pharmacoepidemiologie et d'Informations sur le Medicament 37 all\u00e9es Jules Guesde 31000 Toulouse France"},{"name":"INSERM UMR 1027 Universit\u00e9 de Toulouse 37 all\u00e9es Jules Guesde 31000 Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Moulis","sequence":"additional","affiliation":[{"name":"INSERM UMR 1027 Universit\u00e9 de Toulouse 37 all\u00e9es Jules Guesde 31000 Toulouse France"},{"name":"Service de M\u00e9decine Interne Centre Hospitalier Universitaire de Toulouse Place du Docteur Baylac \u2010 TSA 40031 \u2010 31059 Toulouse cedex 9 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malak","family":"Abou Taam","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de PharmacoVigilance Centre Hospitalier Universitaire de Reims Avenue du G\u00e9n\u00e9ral Koenig 51092 Reims France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Medicale et Clinique Centre Midi\u2010Pyrenees de PharmacoVigilance de Pharmacoepidemiologie et d'Informations sur le Medicament 37 all\u00e9es Jules Guesde 31000 Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Chebane","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Medicale et Clinique Centre Midi\u2010Pyrenees de PharmacoVigilance de Pharmacoepidemiologie et d'Informations sur le Medicament 37 all\u00e9es Jules Guesde 31000 Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Petitpain","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de PharmacoVigilance Centre Hospitalier Universitaire de Nancy 29 avenue du Mar\u00e9chal de Lattre de Tassigny 54035 Nancy cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadette","family":"Baldin","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de PharmacoVigilance H\u00f4pital de Cimiez BP 1179 06003 Nice cedex 1 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gr\u00e9gory","family":"Pugnet","sequence":"additional","affiliation":[{"name":"INSERM UMR 1027 Universit\u00e9 de Toulouse 37 all\u00e9es Jules Guesde 31000 Toulouse France"},{"name":"Service de M\u00e9decine Interne Centre Hospitalier Universitaire de Toulouse Place du Docteur Baylac \u2010 TSA 40031 \u2010 31059 Toulouse cedex 9 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Louis","family":"Montastruc","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Medicale et Clinique Centre Midi\u2010Pyrenees de PharmacoVigilance de Pharmacoepidemiologie et d'Informations sur le Medicament 37 all\u00e9es Jules Guesde 31000 Toulouse France"},{"name":"INSERM UMR 1027 Universit\u00e9 de Toulouse 37 all\u00e9es Jules Guesde 31000 Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haleh","family":"Bagheri","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Medicale et Clinique Centre Midi\u2010Pyrenees de PharmacoVigilance de Pharmacoepidemiologie et d'Informations sur le Medicament 37 all\u00e9es Jules Guesde 31000 Toulouse France"},{"name":"INSERM UMR 1027 Universit\u00e9 de Toulouse 37 all\u00e9es Jules Guesde 31000 Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-12-98"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23267"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes350"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10939"},{"key":"e_1_2_7_6_1","first-page":"119","article-title":"Crohn's disease and cancer","volume":"80","author":"Fornaro R.","year":"2009","journal-title":"Ann. 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