{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T10:55:51Z","timestamp":1775040951197,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T00:00:00Z","timestamp":1462406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Fundamemntal Clinical Pharma"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>H2 receptor antagonists can be associated with central adverse drug reactions (<jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s), like confusion, delirium, hallucinations, slurred speech or headaches. We report here a \u2018serious\u2019 case of severe mania leading to hospitalization in a 42\u2010year\u2010old alcohol\u2010dependent man, 4 days after ranitidine introduction. Review of literature showed that this \u2018very rare\u2019 <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content> occurs mainly in patients with predisposing factors: age, decrease in renal and\/or hepatic function, polymedication, alcohol. Knowledge of this <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content> can be particularly important for these drugs widely used as self\u2010medication.<\/jats:p>","DOI":"10.1111\/fcp.12201","type":"journal-article","created":{"date-parts":[[2016,4,16]],"date-time":"2016-04-16T06:06:46Z","timestamp":1460786806000},"page":"294-296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mania associated with ranitidine: a case report and review of literature"],"prefix":"10.1111","volume":"30","author":[{"given":"Audrey","family":"Mauran","sequence":"first","affiliation":[{"name":"Department of Medical and Clinical Pharmacology Pharmacop\u00f4le Midi\u2010Pyr\u00e9n\u00e9es Centre Midi\u2010Pyr\u00e9n\u00e9es de PharmacoVigilance de Pharmaco\u00e9pid\u00e9miologie et d'Informations sur le M\u00e9dicament CIC INSERM 1436 Facult\u00e9 de M\u00e9decine Centre Hospitalier Universitaire University of Toulouse Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tudi","family":"Goze","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Medical Psychology Centre Hospitalier Universitaire University of Toulouse Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Abadie","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Pharmacology Pharmacop\u00f4le Midi\u2010Pyr\u00e9n\u00e9es Centre Midi\u2010Pyr\u00e9n\u00e9es de PharmacoVigilance de Pharmaco\u00e9pid\u00e9miologie et d'Informations sur le M\u00e9dicament CIC INSERM 1436 Facult\u00e9 de M\u00e9decine Centre Hospitalier Universitaire University of Toulouse Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Bondon\u2010Guitton","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Pharmacology Pharmacop\u00f4le Midi\u2010Pyr\u00e9n\u00e9es Centre Midi\u2010Pyr\u00e9n\u00e9es de PharmacoVigilance de Pharmaco\u00e9pid\u00e9miologie et d'Informations sur le M\u00e9dicament CIC INSERM 1436 Facult\u00e9 de M\u00e9decine Centre Hospitalier Universitaire University of Toulouse Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Chevrel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Centre Hospitalier Universitaire University of Toulouse Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Medical Psychology Centre Hospitalier Universitaire University of Toulouse Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Louis","family":"Montastruc","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Pharmacology Pharmacop\u00f4le Midi\u2010Pyr\u00e9n\u00e9es Centre Midi\u2010Pyr\u00e9n\u00e9es de PharmacoVigilance de Pharmaco\u00e9pid\u00e9miologie et d'Informations sur le M\u00e9dicament CIC INSERM 1436 Facult\u00e9 de M\u00e9decine Centre Hospitalier Universitaire University of Toulouse Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Montastruc","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Pharmacology Pharmacop\u00f4le Midi\u2010Pyr\u00e9n\u00e9es Centre Midi\u2010Pyr\u00e9n\u00e9es de PharmacoVigilance de Pharmaco\u00e9pid\u00e9miologie et d'Informations sur le M\u00e9dicament CIC INSERM 1436 Facult\u00e9 de M\u00e9decine Centre Hospitalier Universitaire University of Toulouse Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199106020-00002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198711000-00038"},{"key":"e_1_2_7_4_1","first-page":"111","article-title":"Imputation of the unexpected or toxic effects of drugs. 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